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Research Associate, Cancer Cell Biology

Employer
Actalent
Location
Redwood City, California, US
Salary
Competitive
Closing date
Aug 14, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Genetics, Biology
Salary Type
Salary
Employment Type
Full time
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*Description:*
Our client is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
*As a key member in our Biology team, you will: *
 Be a critical contributor to mechanistic biology and precision medicine research fundamental to the discovery of novel anti-cancer agents.
 Utilize pharmacologic and genetic approaches, including CRISPR gene editing, to characterize key oncogenic signaling pathways in order to establish molecular mechanisms underlying response to targeted cancer therapies.
 Maintain cultures of multiple human cancer cell lines and CRISPR-engineered cell lines simultaneously to support experimental efforts.
 Perform molecular biology/bioassays to interrogate effects of inhibitors on cellular pathways - PCR, qPCR, DNA/RNA preparation, Sanger sequencing, cloning, SDS-PAGE/Western blot, MSD etc.
 Prepare next-generation sequencing libraries for targeted gene panels (DNA and RNA) and operate Illumina sequencer.
 Develop and perform plate-based cellular assays using reagent kits (experience with assay automation/robotic liquid handlers would be a plus).
 Analyze data using data analysis software: Excel, GraphPad Prism, and Softmax Pro.
 Be an excellent team member, collaborator, communicator.
 Have an eagerness to learn new techniques.
*Qualifications:*
Required Experience, Skills, and Education:
 Bachelor's degree or Master's degree in Molecular Biology, Biochemistry, Biology, Genetics, or related field.
 2+ years of experience in cell culture/molecular biology role in biotech or academic lab.
 Hands-on experience beyond laboratory coursework with demonstrated proficiency in a variety of cellular and molecular biology techniques (e.g. mammalian cell culture, SDS-PAGE/Western blot, PCR, qPCR, kit-based assays such as CTG, AlphaScreen, MSD).
 Desire to learn and develop functional genomics approaches for applications in oncology.
 Rigorous, quantitative, attention to detail, keen to maximize efficiency.
 Highly organized, detail-oriented, excellent record keeping skills, and calm under pressure.
 Demonstrated ability to meet project deadlines and work efficiently in a fluid environment.
*Experience Level:*
Intermediate Level
*Please be sure to submit your resume with all applications.*
About Actalent:
Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions. The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

About Actalent:

Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.

The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.
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