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Postdoctoral Researcher (DEP Biology)

Employer
Oregon Health & Science University
Location
Portland, Oregon, US
Salary
Competitive
Closing date
Aug 10, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Energy, Biology
Salary Type
Salary
Employment Type
Fellowship
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Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal, one that requires novelty, creativity, and innovation. We are composed of biologists, chemists, biomedical engineers, computationalists, and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality, to create a global early detection community, and to have a positive impact on the Oregon economy.

CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.

The OHSU Fellowship for Diversity in Research seeks to address the need for increased representation of minoritized races/ethnicities in STEM at the postdoctoral level. Eligible candidates are encouraged to apply. Visit www.ohsu.edu/ofdir for more information.

Every Knight Cancer employee is expected to embody our guiding principles:
  • We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
  • We SUPPORT each otherRespect leads to trust, which leads to excellence
  • We work as a CONNECTED team We must leverage our collective brain power to conquer cancer because no one individual can do it alone

Cancer Early Detection Advanced Research Center (CEDAR) is currently hiring for 1-2 highly motivated fellows with expertise in Biology and Cancer Biology to work in the following general areas:
  • Study the biology of different cancer-derived nanoparticles released into circulation purifying nanoparticles from patient plasma samples using new dielectrophoresis recovery technology (Gustafson, et al. 2021). This work will explore the different types of nanoparticles and the cancer-related biomarkers they carry using their unique dielectric properties to separate them from bulk plasma samples (Ibsen et al. 2017). This includes collection of the particles using dielectrophoresis technology, determining their cellular origin, and detection of their cancer-related biomarkers using different immunostaining and signal amplification techniques. This position will utilize the high-end specialized dielectrophoresis equipment located here at OHSU. This will also involve antibody validation techniques, quantitative fluorescent microscopy imaging, TEM imaging, particle characterization, and innovative approaches to sample handling.
  • Cancer biomarker panel efficacy determining what nanoparticle-associated biomarkers can be combined into a panel that is capable of distinguishing early stage cancer patients from healthy controls. The goal is to develop techniques that will bring extracellular vesical diagnostics to the clinic for the first time through the use of the new dielectrophoresis based collection technology. The panel will be used to determine the sensitivity and specificity of the extracellular vesicle associated biomarkers. This will also explore the cancer biology that meads to the overexpression of these different biomarkers and the heterogeneity of expression between patients.

A successful candidate will have the opportunity to work closely with Dr. Stuart Ibsen and other CEDAR researchers to develop key technology platforms involving liquid biopsy techniques that use dielectrophoresis to recover cancer-derived nanoparticles directly from patient plasma samples. These particles carry cancer-related biomarkers and we are constructing a panel of these biomarkers to detect and diagnose cancer.

References:
  • Gustafson, Kyle; Huynh, Katherine; Heineck, Daniel; Bueno, Jesus; Modestino, Augusta; Kim, Sejung; Gower, Austin; Armstrong, Randall; Schutt, Carolyn; Ibsen, Stuart. Automated Fluorescence Quantification of Extracellular Vesicles Collected from Blood Plasma using Dielectrophoresis. Lab on a Chip, Volume 21, Issue 7: pp. 1318-1332. (2021) (Back Cover)
  • Sarno, Benjamin; Heineck, Daniel; Heller Michael J.; Ibsen, Stuart. Dielectrophoresis: Developments and Applications from 2010 to 2020. Electrophoresis, Volume 42, Number 5, pp. 539-564 (2021). (Cover)
  • Ibsen, Stuart; Wright, Jennifer; Lewis, Jean; Kim, Sejung; Ko, Seo-Yeon; Ong, Jiye; Manouchehri, Sareh; Vyas, Ankit; Akers, Johnny; Chen, Clark; Carter, Bob; Esener, Sadik; Heller, Michael."Rapid isolation and detection of exosomes and associated biomarkers from plasma." ACS Nano, Volume 11, Issue 7, pp. 6641-6651 (2017).
  • Manouchehri, Sareh; Ibsen, Stuart; Wright, Jennifer; Rassenti, Laura; Ghia, Emanuela; Widhopf II, George; Kipps, Thomas; Heller, Michael. Dielectrophoretic Recovery of DNA from Plasma for the Identification of Chronic Lymphocytic Leukemia Point Mutations." International Journal of Hematologic Oncology, (2016).
  • Ibsen, Stuart; Sonnenberg, Avery; Ibsen, Carolyn; Mukthavaram, Rajesh; Yeh, Yasan; Ortac, Inanc; Manouchehri, Sareh; Kesari, Santosh; Esener, Sadik; Heller, Michael. "Recovery of Drug Delivery Nanoparticles from Human Plasma using an Electrokinetic Platform Technology." Small, (2015).
  • M.D., M.D./Ph.D., or Ph.D.
  • Minimum of 3 years as a graduate student
  • Specialty: Cancer Biology or related field, Cell Biology
  • Excellent communication, analytical and organizational skills
  • Ability to work independently and as part of a team while being collaborative in resolving problems
  • Passion for science and inquiry
  • Ability to synthesize ones own results and others to formulate hypotheses
  • Must possess energy and drive to coordinate multiple projects simultaneously
  • Ability to use tact and diplomacy to maintain effective working relationships
  • Ability to synthesize scientific projects and communicate science to diverse audiences
  • Experience with immunostaining and antibody validation
  • Experience with data analysis

Apply online. Please be sure to upload a Cover Letter and Resume/CV.

Effective Oct. 18, 2021, all OHSU employees were required to be fully vaccinated against COVID-19 unless they had an approved medical or religious exception. If you are hired by OHSU, you will need to be fully vaccinated (or obtain an approved exception) prior to starting work, and need to provide proof of vaccination (or approved exception) within 10 days of starting work.

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Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.

Recruitment ID: 2022-15408

Street: Waterfront

Job Type: Postdoctoral

Posting Department: CEDAR - Knight Cancer Institute

Posting Pay: DOE

Posting FTE: 1.00

Posting Hours: 8:30 am - 5:00 pm, occasional nights and weekends

Posting Schedule: Monday through Friday

HR Mission: School of Medicine

Drug Testable: No

AAEO Language: Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

As an organization devoted to the health and well-being of people in Oregon and beyond, OHSU requires its employees to be fully vaccinated against COVID-19.
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