Job Scope & Purpose:
Our leading edge, start-up client is working to revolutionize genomic medicine with tRNA to improve outcomes for patients suffering with life-threatening, multigenic diseases. This team is seeking an experienced, start-up minded, Vice President of Biology to serve a critical role in bringing a new class of precision medicines to the clinic. Foundationally, you will be an expert in small molecule oncology with significant exposure to various RNA applications or targets. A go-getter mindset with the ability to be averse to challenges and pliant to changes will be a must.
Primary Job Responsibilities:
- Establish the strategic direction of the R&D function. Build and oversee preclinical discovery programs and translational science strategy-from concept through IND submission.
- Help launch an R&D headquarters in Boston, MA.
- Expand The internal target validation, assay development and critical reagent development capabilities.
- Oversee the design, execution, and interpretation of non-clinical pharmacology and toxicology studies. And the preparation of successful IND submissions for a tissue-agnostic, pathophysiology-driven approach, leveraging subject matter experts and demonstrating a passion for science.
- Cultivate a network of collaborative relationships with CROs, serving as the point-of-contact for external discovery work.
- Collaborate with the leadership team to advance business development focus on partnering and creating value for our internal programs and assets.
Primary Job Requirements:
- PhD in Biology, Pharmacology or related discipline.
- 15+ years of productive industry-based drug discovery experience with a background in oncology.
- Proven track record advancing programs from target ID to development candidate nomination.
- Strong understanding of biology/pharmacology and best practices for moving an NCE/NME through IND-enabling studies towards regulatory submission.
- Demonstrated experience leading small molecule oncology projects from concept to development.
- Extensive new target discovery and biological target validation experience using a multitude of modalities, including CRISPR and RNAi.
- Deep knowledge in molecular and cellular biology, in vitro assay development and in vivo tumor models (including patient-derived xenografts).
- Extensive knowledge in disciplines relevant to small-molecule drug discovery including cell biology, pharmacology, DMPK, and safety assessment.
- Experience advancing drugs against novel targets to IND stage in diverse therapeutic areas and molecular target classes.
- Involvement throughout the early stages of clinical development.
- Success in recruiting, building, and managing a high-performing team.
Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.
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