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PhD Scientist, Biology

PTC Therapeutics
South Plainfield, New Jersey, US
Closing date
Aug 19, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Job Description Summary: The Scientist , Biology is responsible for planning and performing scientific experiments that contribute to PTC's research and drug discovery activities. The Scientist is also responsible for communicating experimental results to his/her supervisor and the project team. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC's discovery science project teams. S/he also supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate. Job Description: ESSENTIAL FUNCTIONS Primary duties/responsibilities: * With guidance from the advisor plans, initiates, directs, and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s). This includes performing analyses of primary research literature. * Presents findings internally to cross-functional teams. * Maintains a detailed laboratory notebook. * Interviews and contributes to the evaluation of candidates. * May provide scientific advice to research leadership on projects and areas of expertise. * May Participate in the development and writing of patent applications. * Abides by all safety and regulatory requirements and guidelines. * Performs other tasks as assigned. * Contributes to general lab needs such as: * Equipment maintenance * Capital equipment purchases * Troubleshoot KNOWLEDGE/SKILLS/ABILITIES REQUIRED * Minimum level of education and years of relevant work experience. * Ph.D. in scientific discipline preferably in Molecular Biology or Biochemistry with 1-2 years' post-doctoral or Industry experience. * Special knowledge or skills needed and/or licenses or certificates required. * Hands on experience with mammalian cell culture. * Hands on experience with nucleic acid isolation and quantification, as well as protein quantification and analysis methods (e.g., RT-qPCR, Western blot, ELISA, MSD). * Hands on experience and strong knowledge of CRISPR genome editing technology. * At least one first-author paper published or accepted for publication. * Ability to work collaboratively under direct supervision, in a fast-paced, matrixed, team environment. * Excellent planning, organization, and time management skills. * Demonstrate ability to work on complex problems to produce experimental data across one or more projects. * Exercises independent judgement within defined procedures and practices. * Possesses detailed and expert knowledge of scientific principles and concepts. * Demonstrate ability to work effectively in a multi-disciplinary team environment. * Proficiency with Microsoft Office preferably MS Excel and MS PowerPoint or similar * Excellent verbal and written communication and skills. * Analytical thinker with excellent problem-solving skills. * Demonstrates an understanding of the strategic alignment of his/her work with corporate goal(s) and demonstrates the ability to adapt to changing priorities and deadlines. * Special knowledge or skills and/or licenses or certificates preferred. * Experience in characterizing on- and off-target of in-vitro or in-vivo genome editing using CRISPR technology. * Experience in gene therapy and AAV biology (AAV vector design, production, QC, transduction, etc). * Experience in working with iPSC. * Knowledge of neuroscience, neurological or neuromuscular disorders, nucleotide-repeat disorders (NRDs), eg. C9-ALS, HD, FA, FXS, SCAs etc. * Demonstrated knowledge and understanding of RNA biogenesis, regulation, and turnover and its role in eukaryotic gene expression (e.g., pre-mRNA splicing, miRNA, NMD, etc.). * Experience in tissue processing and familiarity with animal studies. * Travel requirements Up to 10% * Physical requirements (only note if the job requires physical capacity beyond general office work) Office/Laboratory based position At PTC Therapeutics we are seeking candidates in the United States who are fully vaccinated against COVID-19 or who will be fully vaccinated by the time they begin the position. EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page

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