Director, Genomics Core

Employer
Brigham and Women's Hospital
Location
Boston, Massachusetts, US
Salary
Competitive
Closing date
Aug 16, 2022

View more

Sector
Academic / Research
Field
Informatics / GIS
Discipline
Genetics
Salary Type
Salary
Employment Type
Full time
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Job Description - Director, Genomics Core (3185115)

Job Description

Director, Genomics Core - ( 3185115 )

Description

We are seeking a Director for the Genomics and Technology Core (GTC) in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH). The GTC is a centralized collaborative center for genomics applications across the CGM and MGH. The CGM is a hub of genomic medicine research that includes faculty leadership across MGH departments as well as the Broad Institute of MIT and Harvard. The GTC provides expertise in molecular genomics and bioinformatics to this community of almost 50 faculty and 400 researchers, and the activities in the GTC are closely tied to related genomics cores at MGH and the Broad Institute. The overall research environment in the CGM includes molecular and computational genomics research programs across the ‘Genomic Medicine Cycle' that envisages integrated research programs engaged in large-scale population genetics, disease association, functional mechanism, and translational therapeutics and genomic diagnostics research. The CGM includes faculty across nearly a dozen MGH departments and Centers and encompasses four thematic Units, including the Molecular Neurogenetics Unit (MNU Director: James Gusella, Neurology), the Analytical and Translational Genetics Unit (ATGU Chief: Mark Daly, Medicine), the Psychiatric and Neurodevelopmental Genetics Unit (PNGU Director: Jordan Smoller, Psychiatry), and the Genomic Medicine Unit (GMU Director: Heidi Rehm, Medicine). The GTC provides all forms of sample extraction, library production, sequencing, and bioinformatic analyses for genomics applications from our faculty and other MGH collaborators. The candidate will be expected to have extensive experience in genomics technologies and techniques and will provide oversight, management, and hands-on research to the Core. The GTC director will report to the CGM Director, Dr. Michael Talkowski, and will oversee a team of individuals working within the Core as well as the Talkowski laboratory.

The successful candidate will be a results-focused, team-oriented, creative molecular geneticist who is able to manage individuals, programs, and faculty interactions in a highly interdisciplinary and collaborative genomic medicine environment. The candidate must be self-motivated, detail-oriented and exhibit strong problem-solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and leadership groups in achieving research goals.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Laboratory Training and Leadership:
  • Supervise molecular genetics technicians and/or staff scientists to generate libraries and data using state-of-the-art genomics methods and technologies.
  • Coordinate with faculty, project leaders, and team members to ensure proper integration of data and workflow.
  • Train staff on new and existing techniques and protocols.
  • Closely integrate and coordinate with the Broad Institute Genomics Platform.

Laboratory Maintenance:
  • Manage personnel including training, assignments and schedules to meet milestones and deadlines.
  • Manage submissions and create projections of data generation needs, timelines, and costs.
  • Manage all equipment and consumable purchasing and maintenance.

Data Management:
  • Maintain project records.
  • Perform basic analysis of genomics library metrics in tandem with the GTC Bioinformatics team.
  • Prepare and present reports to PI and lab members.

Development and Execution of Experimental Protocols:
  • Must be experienced with the handling and manipulation of biological samples (e.g., tissue, blood, cells) from a variety of specimens (e.g., human, mouse, invertebrates).
  • Perform and oversee high quality library generation for genomics workflows.
  • Determine the most suitable methodology and protocols for proposed experiments.
  • Design, modify and standardize protocols based on state-of-the-art techniques and current literature.
  • Troubleshoot problems with experiments, protocols, and instruments.
  • Generate cost projections and timelines for experiments and projects.
  • Oversee project billing.
  • Establish and maintain annual and quarterly GTC budgets in coordination with the CGM Finance Management team.
  • Prepare written and/or verbal financial reports.

Participation in Publication:
  • Prepare written and/or verbal status reports.
  • Organize materials and analyze data for publication or presentation.
  • Draft materials for the preparation of research presentations, manuscripts, and grants.
Qualifications

SKILLS & COMPETENCIES REQUIRED:
  • Extensive expertise (5+ years) in molecular genomics techniques and library generation (e.g., genome, exome, RNAseq, HiC, ATACseq, ChIPseq, scRNAseq, cell free fetal DNA [cffDNA] sequencing) and technologies (e.g., Illumina, PacBio, ONT).
  • Ability to troubleshoot library construction and sequencing results.
  • Ability to work independently and as a team member.
  • Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
  • Ability to function with speed, precision, and an understanding of the theory behind protocols and experiments.
  • Excellent organizational and communication skills.
  • Outstanding interpersonal skills and the ability to supervise and train scientific staff.

EDUCATION:

Doctoral degree required.

Field of Study/Additional Specialized Training: Genetics, genomics, molecular biology

Equivalent Experience: MS also accepted with 5+ years of research experience

EXPERIENCE:

Required: 5+ years of experience in a research-related field

Preferred: Additional experience as a postdoc preferred

SUPERVISORY RESPONSIBILITY (authority to hire, promote, or terminate):

May supervise Laboratory Assistants, Technicians, Technologists, and/or students.

WORKING CONDITIONS:

Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus, in Boston, MA.
Primary Location
Work Locations : MGH 185 Cambridge 185 Cambridge Street Boston 02144
Job
Organization : Massachusetts General Hospital(MGH)

Schedule : Full-time

Standard Hours : 40

Shift : Day Job

Employee Status : Regular

Recruiting Department : MGH Center for Genomic Medicine

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