The Siegelin lab within the Department of Pathology and Cell Biology is hiring a postdoctoral research scientist to begin immediately. The lab has a significant translational research focus and investigates novel treatments for malignant brain tumors by interrogating tumor cell metabolism, the epigenome and cell death mechanisms. Recent publications by our group that are representative of our current work are:Nat Commun. 2021 Sep 1;12(1):5203. doi: 10.1038/s41467-021-25501-x.
J Clin Invest. 2020 Jul 1;130(7):3699-3716. doi: 10.1172/JCI129049.
Nat Commun. 2017 Oct 20;8(1):1067. doi: 10.1038/s41467-017-00984-9.
To study these aspects, cell culture (stem-like glioblastoma cells, patient-derived xenograft cultures) and orthotopic glioblastoma in vivo models are being used as the main models. Genetic approaches, including but not limited to lentiviral/adenoviral based gene silencing (shRNA)/knock-out (CRISPR/Cas9)/overexpression techniques are implicated in our studies. Genetic and epigenetic techniques include ATAC-seq, CHIP-seq, RNA-seq or standard microarray analysis with basic bioinformatics skills. Metabolism is mainly investigated by extracellular flux analysis and stable isotope tracing studies.
The CUMC Dept of Pathology and Cell Biology a world-class group of investigators that is one of the top-ranked Pathology Departments in the country that provides a supportive and collegial environment with extensive opportunities for professional development and advancement to top tier careers in academia and industry. Its location on the Upper West Side of Manhattan enables access to the multiple sites of interest, culture, and lifestyle in New York City.
Ph.D. M.D. or MD/Ph.D. Competitive candidates for this position should be self-motivated and highly dedicated to science. The candidate should display efficient organization and be able to prioritize assignments/tasks. Outstanding oral, written, and interpersonal communication skills are required as is the ability to work both independently as well as collaboratively in a multidisciplinary environment. It is expected that the candidate can assist in teaching graduate students during their rotations. We strongly encourage and favor grant applications for our trainees and are highly dedicated to their career advancement.
Columbia University is an Equal Opportunity Employer / Disability / Veteran