Principal Scientist, Tumor Biology

Job Description

We are looking for a Principal Scientist with extensive experience studying the tumor microenvironment (TME) to join our Tumor Biology group. The successful candidate will have prior experience researching the interplay between tumor cells and various stromal cell types that support tumor growth and development and a deep understanding of the role that stromal cells play in mediating drug resistance, including knowledge of the extracellular matrix (ECM) components of the TME that may limit therapeutic efficacy. Prior experience in tumor/stromal cell in vitro co-culture systems for modeling the in vivo stromal compartment is required. The successful candidate will have prior experience serving as a project team lead and/or a biology representative for an oncology small molecule drug development program. The successful candidate will be responsible for designing and executing cutting-edge research programs, as well as for reviewing/presenting target proposals, proposing and performing target validation studies, and developing and validating cell-based assays for drug screening. This role supports the oncology pipeline by working directly with the Senior Director of Tumor Biology on the overall research program direction, establishing decision-making cascades, aligning on go/no-go decisions, timelines, and resourcing required for success.