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Scientist Oncology Early Target Biology

Bristol Myers Squibb
Cambridge, Massachusetts, US
Closing date
Jul 29, 2022

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Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities.

The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The Scientist will join the Oncology Early Target Biology group at Bristol-Myers Squibb (BMS) in Cambridge, MA to aide in the advancement of early-stage therapeutic targets. The position will utilize genome engineering, mechanistic biology, cell-based assays, and other cutting-edge technologies to validate tumor intrinsic targets and support the drug discovery pipeline. The qualified candidate is a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment and aid the advancement of the next wave of targets into preclinical drug development. The candidate is expected to effectively collaborate with colleagues across discovery oncology including the exploratory pharmacology, drug discovery and translational research groups. The position requires the ability to design, iterate, and lead several key project initiatives and demonstrate critical thinking to challenge self and others. The successful candidate will demonstrate clear and professional verbal and written communication skills and will be capable of communicating their results across multidisciplinary teams.

Position Responsibilities

In the role as a Scientist within Early Target Biology , the ideal candidate:
  • Applies scientific and technical skills and functional knowledge to conduct experiments / research / studies in assigned area
  • May adapt standard methods and techniques by applying breadth of knowledge and prior work experience
  • Makes decisions that impact entire work group / project team
  • May contribute to initiatives related to continuous improvement or development of new approaches / technologies
  • Makes presentations in small, multidisciplinary meetings, logically presenting information to convey clear, key messages
  • May represent department or function on program / project team or sub-team

Experience Required

Bachelor's Degree
  • 5+ years of academic and / or industry experience


Master's Degree
  • 3+ years of academic and / or industry experience


Ph.D. or equivalent advanced degree in the Life Sciences
  • No experience necessary

Preferred Qualifications:
  • Strong scientific and hands-on experience using a wide range of cellular and molecular biology techniques, including tissue culture, flow cytometry, western blotting, Immunoprecipitation, development of reporter assays, MSD, ELISA, use of genetic perturbation techniques (eg shRNA,siRNA CRISPR-mediated genome editing), qRT-PCR, cell proliferation assays, lentivirus generation and transduction
  • Experience in forward and reverse genetic screening followed by target validation studies to elucidate mechanistic biology and oncogenic SAR is preferred.
  • Proficiency in utilizing software such as Graph Pad, FlowJo, Microsoft office etc. for data analysis and figure generation is required.
  • Ability to lead, design, and execute on project initiatives and operates to a high standard. Attention to detail with excellent organizational and record keeping skills is a requirement.
  • This position is located in Cambridge, MA. There will be less than 10% travel.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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