This job has expired

Analytical, Microbiology Lead

Employer
Synlogic
Location
MA, Massachusetts, US
Salary
Competitive
Closing date
Jul 6, 2022

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Genetics, Biology
Salary Type
Salary
Employment Type
Full time
You need to sign in or create an account to save a job.
Full-time Estimated: $100,000 - $140,000 a year

Qualifications
  • Clinical trials
  • Research
  • CGMP
  • Flow cytometry
  • Doctor of Philosophy
Full Job Description
COMPANY OVERVIEW:
Synlogic is a clinical-stage biotechnology company developing medicines through its proprietary approach to synthetic biology. Synlogic's pipeline includes its lead program in phenylketonuria (PKU), which has demonstrated proof of concept with plans to start a pivotal, Phase 3 study in the first half of 2023, and additional novel drug candidates designed to treat homocystinuria (HCU) and enteric hyperoxaluria.

The rapid advancement of these potential biotherapeutics, called Synthetic Biotics, has been enabled by Synlogic's proprietary, reproducible, target-specific drug design. Synlogic uses programmable, precision genetic engineering of well-characterized probiotics to exert localized activity for therapeutic benefit, with a focus on metabolic and immunologic diseases.

We combine Human Logic and Science Logic to drive meaningful work, careers, and life at Synlogic. We foster a people-focused environment grounded in: Compassion, Transparency, Collaboration & Fun, while adopting a patient-focused mindset to inspire: Innovation, Integrity, High Performance, and life -changing Results.

We continue to build and enhance our organization. This position is best suited for professionals who are comfortable working in a growing and adaptable, biotech environment. f you want to challenge yourself and build your career while bringing the transformative potential of synthetic biology to patients then we'd love to hear from you.

Synlogic is committed to creating a diverse and inclusive environment and is proud to be an equal opportunity employer, embracing diversity in all forms. Synlogic hires, trains, compensates, and promotes talented Synlogicians regardless of age, color, disability, gender, gender identity or expression, genetics, national origin, race, religion, sexual orientation, veteran status, and other protected statuses as required by the laws and cultures of the geographies in which we operate. We believe in lifting others both inside and outside of the company, ensuring all of our community has access to opportunities and innovative therapies.

POSITION SUMMARY:
The Microbiology Lead candidate will be a creative and pragmatic scientist who will direct efforts to characterize, test, and facilitate the manufacture of live biotherapeutic product candidates within Synlogic. The scientist will work cross functionally with research and process development to bring novel Synthetic Biotic™ medicines to clinical trials and eventual commercialization. This position requires in-depth troubleshooting experience and knowledge of microbiology and microbial physiology, including factors that influence microbial growth and metabolic activity. A working knowledge of microbe characterization beyond identification and the ability to develop assays which characterize aspects of strain performance is essential. A fundamental understanding of process level manufacturing, and adherence to appropriate GMP SOPs and standards would be considered a plus. This person will be working closely with both the research and development organizations to support assay and analytical needs. As with all roles within a small company, the candidate will be expected to direct research as needed across a multi-functional team , as well as participate in data collection in the laboratory.

KEY ACCOUNTABILITIES/DUTIES:
Lead and define the parameters and processes necessary to characterize strains during discovery and early development.
Guide the discovery, development, and translation of microbiological/analytical assays to help define critical quality attributes of the drug substance and drug product.
Work closely with project and process development teams to integrate learnings from strain characterization into late stage development, and apply knowledge learned to future programs.
Generate, analyze and summarize data for key decision gates during development and prepare technical reports for development activities.
Support preparation of regulatory/IND submissions, participate in their review and approval.
Contribute to the research/development of strategies to comply with US and international regulatory standards.
Support a learning environment and foster a culture of scientific excellence through training, influence and leading by example.

QUALIFICATIONS & EXPERIENCES:
Required Qualifications & Experiences: The following qualifications and experiences are required for the position:

Ph.D. in microbiology, biochemistry or related discipline with a minimum of 6 years of experience in microbiology research and/or development.
In depth experience and understanding of microbial physiology and growth, with demonstrated understanding of standard assays used to characterize biotherapeutic products or probiotics, as well as, the ability to apply innovative techniques to study bacterial physiology and metabolism.
Knowledge of how analytical methods are used to measure protein and gene expression, including both omics based and single target approaches
Experience developing assays measuring biochemical transformations, such as metabolite consumption in a microbial environment or conversion of enzymatic assay formats for use as potency assays.
Experience working in a cross-functional, matrix organization and the ability to advance multiple projects in parallel.

Preferred Qualifications & Experiences: The following qualifications and experiences are preferred:

Experience working in a GMP regulated environment and developing assays for drug substance or drug product characterization
Development of biological products for clinical and/or commercial-stage
A working network of microbiological contacts across industries to develop a network to drive microbiological techniques.
Cell counting for in vitro and cell-based assays including cellometer or flow cytometry
Experience authoring and reviewing documentation needed for an IND submission or other regulatory agencies

OTHER REQUIREMENTS:
Travel up to 10%; as needed for professional development

VALUES & BEHAVIORS

We are at our best when we combine Human Logic and Science Logic to build great teams and deliver outstanding results. Our 6 values of Compassion, Fun, Trust & Respect, Innovation, Integrity and Results are central to our organization.

Synlogic is committed to creating a diverse and inclusive environment and is proud to be an equal opportunity employer, embracing diversity in all forms. Synlogic hires, trains, compensates and promotes talented Synlogicians regardless of age, color, disability, gender, gender identity or expression, genetics, national origin, race, religion, sexual orientation, veteran status, and other protected statuses as required by the laws and cultures of the geographies in which we operate. We believe in lifting others both inside and outside of the company, ensuring all of our community has access to opportunities and innovative therapies.

Our compassion for patients is the engine that drives our innovation and motivates our sense of urgency; always remembering that patients are waiting. Our compassion for each other creates a safe environment for continuous risk taking and personal development - facilitating a rapidly moving, fast-paced environment. We connect with our colleagues by having fun together.

We take our work seriously and value integrity in producing the highest quality work. We trust each other, respecting all ideas and driving accountability to generate the best results for our patients and team. We encourage openness, direct feedback and transparency in decision-making to enable an inclusive, nimble environment.

We seek individuals who exemplify these behaviors and who encourage others to do the same.
You need to sign in or create an account to save a job.

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert