Scientist I - Neuroscience/Translational Biology
- Employer
- Regulus Therapeutics
- Location
- San Diego County, California, US
- Salary
- Competitive
- Closing date
- Jun 28, 2022
View more
- Sector
- Academic / Research
- Field
- Conservation science
- Discipline
- Modeling, Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Position description and scope:
This position is intended for a highly qualified candidate who desires the opportunity to grow as a drug discovery scientist and project team leader in the fields of microRNA/oligonucleotides and CNS-related therapeutics. The successful candidate will be a hands-on cell and molecular biologist and will provide important research experience and skills for the organization. Reporting to the Senior Director of Biology, the incumbent will have the opportunity to lead-from-the-bench and participate in various aspects of the drug discovery process: from target identification/validation, lead identification/optimization, through to nomination of clinical candidates and assisting in IND-enabling activities. The individual will be primarily responsible for establishing in vitro phenotypic screens and driving hit-to-lead development from the bench. Candidates who possess strong scientific curiosity and have a proven track record of elucidating complex biological processes are encouraged to apply.
Job responsibilities
Position Requirements:
· PhD in Cell and/or Molecular Biology or related discipline; postdoc experience preferred (2-3 years). Candidates with postdoc training in a biotech/pharm industry setting are particularly encouraged to apply.
· BSc/MS in a related discipline, with ~3-6 years of experience in a biotech or pharm industry setting. Demonstrated success in oligotherapeutic research and/or experience in neuroscience desired, but greater preference for candidates with strong technical skills and knowledge in assay development, optimization and screening practices.
· Hands-on experience with disease-based cell modeling is strongly desired (e.g., CNS inflammatory, seizure and neurodegenerative); experience with in vivo disease models and/or ex vivo manipulation of primary cell types or iPSC-derived is a plus.
· Experience working with and managing CROs/academic collaborations is a plus.
· Working understanding of the principles of pharmacokinetics and pharmacodynamics.
Techniques desired:
· Expertise in cell and molecular biology techniques including advanced cell culture, transfection, luciferase-reporter, MSD, ELISA, RNA purification, RT-qPCR, Western blotting and other standard cell-based or biochemical assays are required. Ability to independently troubleshoot, learn new assays and establish new platforms is essential.
· Neuroscience, or disease area-focused background, with experience developing novel assay systems for molecular target characterization and modeling of complex disease processes, such as through application of primary neuronal/glial cultures, patient-derived cell lines, iPSC models and functional phenotyping.
· Experience with tissue/cell-specific targeting for functional delivery of therapeutics is a plus (e.g., aptamer-based delivery, receptor/ligand conjugations).
· Familiarity and interest in NGS analyses and functional genomic approaches is a plus.
· Proficiency in basic computer data analysis and presentation applications: e.g., Microsoft Word, Excel, and PowerPoint.
Competencies:
· Highly effective interpersonal skills, including both written and oral communication skills
· Highly organized, strong analytical skills and attentive to details
· Strong work ethic, ability to work within schedules and deadline
· Team player, intensely committed to success and getting the job done
· Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment
· Self-motivated, ability to work independently while also willing to follow protocols
· Willingness to rapidly learn new laboratory and data analysis methods
· Demonstrated ability to generate reproducible results, and to teach others
This position is intended for a highly qualified candidate who desires the opportunity to grow as a drug discovery scientist and project team leader in the fields of microRNA/oligonucleotides and CNS-related therapeutics. The successful candidate will be a hands-on cell and molecular biologist and will provide important research experience and skills for the organization. Reporting to the Senior Director of Biology, the incumbent will have the opportunity to lead-from-the-bench and participate in various aspects of the drug discovery process: from target identification/validation, lead identification/optimization, through to nomination of clinical candidates and assisting in IND-enabling activities. The individual will be primarily responsible for establishing in vitro phenotypic screens and driving hit-to-lead development from the bench. Candidates who possess strong scientific curiosity and have a proven track record of elucidating complex biological processes are encouraged to apply.
Job responsibilities
- Independently design, develop, validate and perform cell-based and cell-free assays to evaluate and screen the activities of potential microRNA therapeutics, and to elucidate mechanisms of molecular targets.
- Evaluate and establish new assays in support of phenotypic, CNS-related disease modeling processes; optimize screening assay endpoints and readouts in support of early target identification and validation efforts.
- Maintain a high level of understanding for current literature on microRNA biology, disease areas of primary interest and oligotherapeutic technologies; leverage such knowledge to support existing programs and to propose novel opportunities.
- Coordinate, manage and execute studies with external CRO(s) ( in vivo and in vitro ).
Position Requirements:
· PhD in Cell and/or Molecular Biology or related discipline; postdoc experience preferred (2-3 years). Candidates with postdoc training in a biotech/pharm industry setting are particularly encouraged to apply.
· BSc/MS in a related discipline, with ~3-6 years of experience in a biotech or pharm industry setting. Demonstrated success in oligotherapeutic research and/or experience in neuroscience desired, but greater preference for candidates with strong technical skills and knowledge in assay development, optimization and screening practices.
· Hands-on experience with disease-based cell modeling is strongly desired (e.g., CNS inflammatory, seizure and neurodegenerative); experience with in vivo disease models and/or ex vivo manipulation of primary cell types or iPSC-derived is a plus.
· Experience working with and managing CROs/academic collaborations is a plus.
· Working understanding of the principles of pharmacokinetics and pharmacodynamics.
Techniques desired:
· Expertise in cell and molecular biology techniques including advanced cell culture, transfection, luciferase-reporter, MSD, ELISA, RNA purification, RT-qPCR, Western blotting and other standard cell-based or biochemical assays are required. Ability to independently troubleshoot, learn new assays and establish new platforms is essential.
· Neuroscience, or disease area-focused background, with experience developing novel assay systems for molecular target characterization and modeling of complex disease processes, such as through application of primary neuronal/glial cultures, patient-derived cell lines, iPSC models and functional phenotyping.
· Experience with tissue/cell-specific targeting for functional delivery of therapeutics is a plus (e.g., aptamer-based delivery, receptor/ligand conjugations).
· Familiarity and interest in NGS analyses and functional genomic approaches is a plus.
· Proficiency in basic computer data analysis and presentation applications: e.g., Microsoft Word, Excel, and PowerPoint.
Competencies:
· Highly effective interpersonal skills, including both written and oral communication skills
· Highly organized, strong analytical skills and attentive to details
· Strong work ethic, ability to work within schedules and deadline
· Team player, intensely committed to success and getting the job done
· Ability to multitask, prioritize, and function in a fast-paced entrepreneurial environment
· Self-motivated, ability to work independently while also willing to follow protocols
· Willingness to rapidly learn new laboratory and data analysis methods
· Demonstrated ability to generate reproducible results, and to teach others
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