Scientist Early Discovery Biology

Scientist Early Discovery Biology

Location: Boston, MA

Monte Rosa Therapeutics is seeking an energetic and self-motivated Scientist/Sr. Scientist to join our innovative team working towards discovery of unique molecular glue degraders for the treatment of targeted patient populations in oncology. This is a lab-based position with early leadership opportunities. The successful candidate will have experience in a variety of cellular and molecular biology techniques and be comfortable learning new techniques as needed. The role will include executing on early discovery biology strategy, leading biology on targets, and mentoring junior lab members. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional teams, as well as demonstrate a high degree of independence and organization.

Principal Duties and Responsibilities

• Validate targets and/or target rationale
• Lead early discovery biology on chosen targets
• Guide, design, and execute the validation of hits from high-throughput screens using cellular assays
• Develop and independently perform an array of molecular biology assays (e.g. viability assays, western blotting, qPCR, and/or NanoBRET) to define mechanism of action of molecular glue degraders
• Participate in team drug discovery efforts to select lead candidate molecules
• Mentor junior lab-based scientists

Experience

• PhD in cell/molecular biology, cancer biology, or genetics with 2+ years' experience in biopharma industry
• Experienced cell and molecular biologist with hands-on experience in oncology small molecule drug discovery
• Experience with a variety of molecular biology methods and assays such as immunoblotting, CRISPr/RNAi, vector design, ELISA/AlphaLisa, and NanoBRET
• Experience preparing drug dilutions and performing drug viability/cytotoxicity experiments
• Experience with target validation
• Experience with external CROs to support project progression and meet deadlines
• Experience leading biology within a cross-functional team
• Protein degradation experience is a plus

Interested Candidates may forward CV and Cover Letter to Careers-US@monterosatx.com or submit your credentials online https://www.monterosatx.com

Monte Rosa Therapeutics rational approach in targeting disease-causing proteins for degradation will deliver pioneering therapies for cancer and other diseases. Delivering this new generation of treatments to the patients requires a conceptual change. Monte Rosa recognizes this urgent need and is missioned to develop innovative protein degraders as a solution. Combining deep knowledge, insight and leading-edge science, our integrated engine is built for that purpose.