The lab for Dr. Prajwal Rajappa is accepting applications for a Research Scientist or Post Doctoral Scientist. Applicants should have either a PhD or MD from backgrounds in Neuroscience, Tumor Immunology or Cancer Biology. Backgrounds in Molecular, Cellular and Developmental Biology will also be considered. Experience with animal tumor modeling, cell sorting and flow cytometry is desired. Additional experience with Genomics/Bioinformatics/Statistics is a plus.
Our vision aims to rapidly translate research discoveries into lasting treatment options for pediatric and young adult patients afflicted with Central Nervous System (CNS) tumors. Specifically, our laboratory is studying the mechanisms that potentiate low to high grade glioma progression. We use transgenic brain tumor mouse models that recapitulate low to high grade glioma progression and correlate our findings with peripheral blood and tumor specimens from patients with CNS tumors. These models also serve as a platform to explore the contribution of the tumor microenvironment and myeloid cells in low grade glioma progression and also test novel therapeutic agents aimed at impairing malignant transformation. To that end, we aim to develop next-generation therapies that modulate the innate immune myeloid cell rich glioma microenvironment. To dissect myeloid cell heterogeneity within gliomas, our lab leverages Next-Generation Sequencing in addition to Single-cell RNA sequencing to elucidate the functional role of these innate immune populations.
Our long-term goals are to use these innovative tools in order to translate our findings into new age clinical trials for patients with gliomas and validate select myeloid cell populations as in-vivo biomarkers that may enhance risk stratification and targeted approaches for this patient population.Duties:
The Research Scientist position will design and lead scientific aspects of a project, such as study design, grant proposal drafting, outcome evaluation, and manuscript writing etc. The candidate must have strong interpersonal skills and capable of working with technical staff to drive the projects forward. The candidate must be able to verbally and visually communicate clearly to all level of stakeholders.
From the results of studies, helps to develop hypotheses for further investigation. With minimal guidance from the PI, prepares technical materials such as abstracts, annual reports, scientific papers, grants, and presentations. Publishes scientific articles in appropriate refereed journals.Requirements:
- PhD or MD in Life Sciences
- Previous postdoctoral experience in informatics, design, or technology related areas.
- Previous publication track record
- Previous grant proposal writing experience highly desired
- Strong desire to learn and highly collaborative
- Exceptional interpersonal and communication skills to interact effectively with all levels of the organization and external contacts.