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Scientist IV (ADC Biology)

Employer
Exelixis
Location
Alameda County, California, US
Salary
Competitive
Closing date
Jun 28, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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Company Description

Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts, and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.

As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we're seeking to add talented, dedicated employees to power our mission.

Cancer is our cause. Make it yours, too.

Job Description

Discovery Biotherapeutics is seeking an experienced, self-motivated Scientist IV to provide in vitro pharmacology support for the advancement of the biologics portfolio at Exelixis. The successful candidate must have strong pharmacology background in cancer as he/she will support preclinical activities of ongoing and new biologics projects in antibody drug conjugates and bispecific antibodies.

Qualifications

ESSENTIAL DUTIES AND RESPONSIBILITIES:
  • Design and implement efficacy/mechanism of action/pharmacokinetics/biodistribution studies in support of proof-of-concept studies on antibody drug conjugate oncology programs from discovery to lead selection.
  • Design and implement in vitro and ex vivo studies for pharmacological characterization of drug candidates conducted by CROs and in-house as needed.
  • Analyze critical scientific/technical data and interpretation of experiments.
  • Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement.
  • Effectively communicate scientific concepts, findings and interpretation to multi-disciplinary teams.
  • Follow company intellectual property and compliance policies and practices.
  • Comply with company health and safety policies and general laboratory practices.
Supervisory Responsibilities
  • No supervisory responsibilities
Education

EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS:
  • Bachelor's degree in pharmacology or cancer biology or closely related discipline and a minimum of five (5) years of related experience; or,
  • Master's degree in pharmacology or cancer biology or closely related discipline and minimum of three (3) years of related experience; or,
  • Equivalent combination of education and experience
Experience
  • CRO management experience for out-sourcing of in vitro experiments is required.
  • Strong scientific understanding of in vitro pharmacology, PK, PD concepts in cancer biology is essential. Previous experience working with ADCs strongly preferred.
Knowledge/Skills
  • Demonstrated drive for rigorous scientific excellence. Ability to think critically and creatively to identify and solve scientific problems.
  • Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously.
  • Excellent written, oral, and interpersonal communication skills.
  • A strong team player.
  • Proficiency in oncology-based animal tumor models and related animal handing techniques such as routes of dosing (iv, sc, ip, orthotopic, etc.), blood collection, tissue collection, necropsy, tumor measurement, clinical observation, rodent survival surgeries, and imaging modalities.
  • Skillful in mammalian cell culture and related techniques.
  • Good knowledge in Flow cytometry and histology.
  • Advanced knowledge in Excel, Word, PowerPoint, PDF, and Graphpad prism.
  • Good tracking record and report writing.
Working Conditions
  • Environment: primarily working in laboratories or in office
  • Exposures encountered, such as hazardous materials, and extreme cold.
Additional Information

DISCLAIMER

The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
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