Director, tRNA Biology 1268503

Job Scope & Purpose:

Our new and exclusive client just secured a significant Series A financing to progress the development of tRNA. They have a proprietary pipeline of precision protein-editing therapies dedicated to improving patients' lives in a myriad of different genetically defined diseases. This team is seeking a Director, tRNA Biology to drive the progression of their proprietary platform and help to build the internal group. A successful candidate will have significant exposure in molecular biology and has previously built and led an effective research team.

Primary Job Responsibilities:

• The successful candidate will work both independently and as part of a collaborative team to design, plan and execute experiments that support platform and therapeutic development.
• Design, establish and execute robust, high-quality biochemical and cell-based assays to support lead selection and optimization.
• Establish and perform primary and develop functional assays to support hit-to-lead and lead optimization
• Lead development and execution of cell-based assays to assess biological activity of oligonucleotide-based compounds
• Manage relationships with external research facilities
• Report results to scientific team and management in written and oral presentations

Primary Job Requirements:

• PhD in biology, cell biology, molecular biology, immunology or a related discipline with 8-10 years of experience in biotech or pharmaceutical company.
• Extensive hands-on experience in mammalian cell culture, including primary cells
• Expertise in DNA/RNA/siRNA transfection in vitro and ideally in vivo
• Expertise in CRISPR and viral vector delivery is a plus
• Strong expertise in flow cytometry, cell sorting, immunofluorescence and immunohistochemistry
• In-depth knowledge in assay design, optimization, validation, data analysis and interpretation.
• Hands-on knowledge of cellular and molecular biology techniques, such as, but not limited to, western blot, ELISA, qPCR and molecular cloning.
• Critical data analysis, attention to detail, and troubleshooting abilities.
• Excellent communication, organization, and problem-solving skills
• tRNA biology expertise is a significant plus

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

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