Scientist, Computational Biology, US Biology Oncology Discovery

Janssen Research and Development, Inc., a division of Johnson & Johnson's Family of Companies, is recruiting for a Scientist, Systems Biology, Immuno-Oncology Pathway Area Stronghold (IT-PAS) to be located in Spring House, PA. Remote work options may be considered on a case-by-case basis and if approved by the Company.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.

The highly motivated Scientist, Systems/ Computational Biology, will apply computational approaches to analyze large cancer related OMICs datasets and employ systems biology techniques to interpret data and generate actionable hypotheses. This individual will work in close collaboration with discovery scientists in IT-PAS, Translational Research, Therapeutics Discovery, Data Sciences and Early and Late Clinical groups to guide their study design and facilitate generation of high quality experimental data. With a focus on understanding the interplay between immune and malignant cancer cells in tumor micro-environment, the candidate will analyze, integrate and interpret high dimensional data from a variety of Next Generation Sequencing (NGS) platforms (RNA/DNA/Single cell), microarrays and flow cytometry-based readouts (CyTOF, Cytek Aurora).

The Scientist, Systems/Computational Biology will apply bioinformatics and systems biology methods to support target discovery programs and provide insights on disease biology and drug resistance mechanisms. The candidate will integrate internal datasets with data from external sources (TCGA, ICGC, GTEx, NCBI GEO, COSMIC, UCSC Genome Browser, Single cell atlas) and evaluate and develop novel algorithms for data analysis.

The individual will communicate results to bench scientists, clinicians, and management in an appropriate biological context. The candidate will participate in IT-PAS meetings and proactively support related Bioinformatics and Computational Biology projects. The candidate will maintain compliance with all internal requirements for data integrity and reproducible research, actively work with the internal and external scientific and technical community and participate in technology evaluations and software/database usage training.

Qualifications

• A Masters Degree in computational biology, bioinformatics, biostatistics or related quantitative field with a minimum of 3 years of relevant experience working on bioinformatics projects OR Ph.D. in Bioinformatics, Computational Biology, Biostatistics or related field is required.
  
• Documented experience in NGS based analysis (DNA/RNA-seq) is required
  
• Strong R programming skills are required
  
• Knowledge of machine learning algorithms, exploratory data analysis, pathway data
  
  analysis, statistical modeling and techniques is preferred.
  
• Other high level programming (Python, C/C++, JAVA) experience is preferred
  
• Single cell analytics experience (Seurat workflow) is preferred
  
• High dimensional flow cytometry data analysis is preferred
  
• Oncology/Immunology experience is preferred
  
• Excellent communication, inter-personal, and written skills are required
  
  We strongly encourage individuals with a hybrid background in computational and experimental biology to apply.
  
  Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
  
  ERADICATECANCER
  

Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads

Other Locations

North America

Organization

Janssen Research & Development, LLC (6084)

Job Function

R&D

Requisition ID

2206039161W