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Associate Director/Director, Discovery Biology and Pharmacology

MA, Massachusetts, US
Closing date
Jul 4, 2022

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Academic / Research
Conservation science
Modeling, Biology
Salary Type
Employment Type
Full time
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Associate Director/Director, Discovery Biology & Pharmacology

Cambridge, Massachusetts

Full-time - On-site 60%, Remote 40%

Our client, a Cambridge based startup, is revolutionizing RNA delivery by leveraging new biology along the RNA-Glycobiology axis. Founded by world-experts in glycobiology and glyco-chemistry, they recently launched to harness the potential biology of glycoRNAs for delivery and immune modulation. Reporting to the Co-Founder, you will be directing the discovery biology team. You will be responsible for synthesizing data across disparate assays to form a hypothesis for a lead compound and target in vivo, and then design future in vitro and in vivo experiments to define a disease context in which this molecule is efficacious. This role requires knowledge of IND enabling experience and these assays will comprise the discovery pharmacology sections of future INDs.
  • Manage a team of 3+ scientists internally and external CRO FTE's in design and execution of translational studies
  • Provide expertise in hit-to-lead, SAR, and in vivo modeling assays and studies to team and oversee studies
  • Manage and oversee assay activities performed at CROs/CDMOs associated with data generation and analysis
  • Contribute to written pharmacology section of INDs
  • Design in vivo dosing experiments and oversee execution of modeling done with external CRO partners
  • Present research on a weekly basis to company leadership, and quarterly to investors and BOD
  • Maintain excellent written documentation of completed experiments (e.g. electronic lab notebook and study reports)

  • PhD molecular biology, biochemistry, immunology, biotechnology, or related field and 5+ years of industry experience
  • Experience in mentoring and managing lab teams with proven management experience
  • Previous experience with Hit-to-lead, SAR, and Validation stage compound decision making
  • Previous experience with contributions IND enabling studies
  • Ability to design and oversee in vivo modeling studies with CRO parnterships
  • Excellent writing and communication skills

All resumes will be kept strictly confidential until you choose to pursue a specific opportunity with one of our clients.
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