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Principal Scientist, T Cell Biology

Sonoma Biotherapeutics
South San Francisco, California, US
Closing date
Jun 1, 2022

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Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
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Principal Scientist, T Cell Biology

About Sonoma Biotherapeutics:

Sonoma Biotherapeutics is a South San Francisco and Seattle-based company leading the development of adoptive Treg therapies cell for autoimmune and degenerative diseases. Using next-generation genome editing and target-specific cell therapy, Sonoma is focused on developing its best-in-class platform across the entire spectrum of Treg cell therapeutic capabilities. Founded by pioneers in Treg biology and cell therapy, the company brings together leading expertise and proprietary methodologies for the discovery and development of disease modifying and curative therapies. More information at

Job Purpose/Summary:

We are seeking an independent and self-motivated Principal Scientist to be a contribute to our synthetic biology projects in the Product Validation group in Seattle. You will aid in the project strategy design, execution and reporting of data for IND enabling studies. The ideal candidate will bring new ideas to the table around assay development for implementing in our products, think outside the box, and be motivated to apply science-based concepts into new cellular products. The incumbent should be highly independent with expertise in T cell-based assays. We would like candidates with a strong immunology background and initiative to dive into a fast-paced new startup.

Roles and Responsibilities:

  • Lead projects and independently implement and execute in their experimental design
  • Present projects and communicate them to broader company/ leadership
  • Lead efforts in creative design of new assays for evaluating cellular therapy products in the context of hard to treat autoimmune indications
  • Be hands on in the lab working on all aspects of primary cell therapy product evaluation, from production of the initial product to all the testing and reporting required for IND submission
  • Oversee the activities of lower level personnel
  • Willing to wear many hats as is expected in a startup environment
  • Work in a collaborative, multidisciplinary team and help mentor others

Qualifications and Education Requirements:

  • PhD with 12+ years of experience in immunology, molecular biology or related discipline with relevant lab comprehension.
  • BS or MS with extensive years of experience.

Preferred Skills:

  • Primary cell-based assay development
  • Efficiency across conventional assays for immunology; in vitro proliferation, multiparameter flow cytometry including ICS, ELISA
  • Proficiency in molecular biology techniques as they pertain to cell line development and gene delivery
  • Generation of stable and transient cell lines
  • Experience as a Project Leader and managing junior staff
  • Previous experience with engineered T cells and/or regulatory T cells a plus
  • Previous experience with CAR binder generation or/ or TCR selection a plus

Sonoma Biotherapeutics is an Equal Opportunity Employer

At Sonoma BioTherapeutics, we believe that highest performing teams include people from a wide variety of backgrounds and experiences who respectfully challenge each other. We are committed to building an open, diverse, and inclusive culture for all employees.

Sonoma BioTherapeutics is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, citizenship status, national origin, ancestry, sex, sexual orientation, age, religion, creed, physical or mental disability, medical condition, marital status, veteran status or any other characteristics protected under applicable federal, state and local laws.

We've learned from experience that some of the best people don't always match our requirements perfectly - if you're interested and think you could fit, please don't hesitate to apply. Please submit your resume along with a cover letter to - resumes may also be submitted without applying for a specific job.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited or unable to access or use this online application process and need an alternative method for applying, please contact us at
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