At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology with the goal of enhancing responsiveness to immune checkpoint blockade, targeted and cell therapies. Comprised of scientists across multiple disciplines, we are responsible for the biology and translational science required to support drug development from target identification through first-in-human studies.Position Summary:
We are seeking a Senior Associate Scientist to join the Cancer Biology research team within the Tumor Microenvironment Thematic Research Center at Bristol Myers Squibb in Redwood City, CA. The qualified candidate will aid in the advancement of early-stage therapeutic targets at the intersection of tumor genetics and immuno-biology. The Cancer Biology team is composed of experts in tumor-intrinsic biology, functional genomics, and immune-oncology who develop therapies that leverage the interplay between the host and tumor. Our mission is to provide transformative therapeutics to cancer patients that improve response rates and durability to this challenging disease.
The qualified candidate is a motivated, interactive, and creative biologist possessing the ability to work across a highly collaborative environment to advance preclinical drug development programs from target identification/validation through IND enabling activities. The candidate will be expected to effectively collaborate with colleagues in the oncology, immuno-oncology, in vivo pharmacology, and medicinal chemistry groups. The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams and key stakeholders.Qualifications:
- B.S. in biology or related field with 5+ years or M.S. in biology or related field with 2-5 years' experience in cancer biology, immuno-oncology, or cellular and molecular biology is required. Prior industrial scientific experience preferred but not required.
- Demonstrated experience in experimental design, execution, data analysis and troubleshooting under limited supervision are required.
- Required technical expertise:
- Cell culture: cancer cell line propagation and qualification
- Molecular biology: cloning, nucleic acid sequence analysis, PCR, primer design
- mRNA analysis: cDNA synthesis, RNA quantification, Taqman qPCR
- Protein characterization: western blotting
- Computation: proficiency in Microsoft Office etc. for data analysis and figure generation
- Preferred technical expertise:
- Cell culture: BSL2+ and lentiviral production/transduction
- Molecular biology: gene synthesis (outsourced) and electroporation
- CRISPR/Cas9/sgRNA/RNAi: design, cloning, and implementation of stable knock-in/knock-out experiments in cell lines using transfection and lentiviral delivery. Hands-on functional genomics experience.
- Protein characterization: immunoprecipitation, immunofluorescence, fluorescence microscopy
- Plate based assays: CTG and IncuCyte. Knowledge of or exposure to assays to identify and optimize drug candidates.
- Computation: proficiency in GraphPad Prism and FlowJo. Experience in data mining through use of desktop tools/interfaces and public databases (e.g., UCSC genome Browser, cBIO, GTex, Depmap).
- Excellent interpersonal skills with the ability to collaborate and interact effectively with colleagues is required.
- Ability to mentor more junior scientists and colleagues on laboratory techniques and best practices is highly valued.
- Attention to detail with excellent organizational and record keeping skills is required.
- This is a laboratory-based position in Redwood City, CA. There will be less than 10% travel.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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