Scientist, Chemical Biology

Company Overview:

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered "undruggable". Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We are uniquely structured with opportunities for all scientists to contribute to both established programs as well as ongoing early target selection, screens and validation. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Job Summary:

The successful candidate will have extensive hands-on experience and expertise in the evaluation of the impact of small molecules on protein function and stability both in vitro and in a cellular context via cell and/or biochemical assay development. This position will be responsible for leading/supporting efforts towards the validation of novel drug targets via multiple mechanisms, including testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion's proprietary chemical proteomics platform.

Education and Experience requirements:

• PhD and post-doc experience in biochemistry, chemical biology, cell biology or related disciplines
• Required technical skills include a strong molecular biology skill set (e.g., DNA cloning, site-directed mutagenesis, CRISPR, transient transfection, viral transduction, gene expression analysis), Protein expression analysis (western blot/ ELISA/ProteinSimple), mammalian cell culture, microscopy and functional/phenotypic assays (Cell Viability 2D and 3D, Soft agar, Apoptosis)
• Understanding of basic chemical principles and structure-activity relationships is desired
• Working knowledge of mass spectrometry based analyses for chemical proteomics investigations is a plus
  
  

Required Key Attributes:

• Candidates must have strong communication skills as evidenced in public presentations and/or peer reviewed literature.
• Candidates must have effective troubleshooting and problem-solving skills.
• Candidates must be an effective team player, strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines.
  
  

Further Information:

In addition to a competitive compensation package with long-term incentives and 401k match, Vividion also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, life, and disability insurance.

Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Privacy Policy:

The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please see https://vividion.com/publication/privacy-policy/.

Powered by JazzHR

L7kb9qDipv