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Scientist - Cell Biologist / Immunologist

Employer
ATUM
Location
Newark, California, US
Salary
Competitive
Closing date
May 31, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Other
Salary Type
Salary
Employment Type
Full time
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Looking to broaden your experience in a dynamic, technology-rich, and employee-centric environment? Here's an opportunity to work in a collaborative research-oriented team in a company with a track record in finding innovative solutions to difficult biotechnological problems.

ATUM (www.atum.bio) is a 19-year-old, world-leading bioengineering company of ~140 people. It conducts research to advance its many in-house technology platforms and - especially - to develop new ways to apply them to solve important biotechnological or pharmaceutical deficiencies. The company has state-of-the-art capabilities in machine learning-assisted synthetic biology, and a suite of innovative technologies spanning protein and cellular engineering, gene synthesis, gene transfer, protein expression and manufacturing. It provides diverse - and often highly tailored - solutions to a broad range of clients across the globe.

ATUM is seeking a scientist with expertise in cell biology for a laboratory-focused research and development role. ATUM places a premium on enthusiasm for contributing to projects at all levels: from concept through design to experimentation and data analysis. The new scientist will participate in projects that have an immunological orientation but rely on core molecular biological and cell biological methodology. Immunological expertise would be an asset but is not essential. The projects are expected to involve machine-learning-assisted protein engineering, extensive use of ATUM's Leap-In transposition technology, engineering of primary and transformed cells, and the use and development of novel transcriptional reporter systems.

The ideal candidate will be independent but embrace collaboration and should have an affinity for exploiting advanced technologies to solve complex biological research problems. Flexibility, a capacity to multi-task, and an openness to switch course when needed are all essential attributes.

Requirements

Education and Experience
  • A Ph.D. in Molecular Biology, Biochemistry, Cell Biology, Immunology, or a related field.
  • Alternatively, a B.S. or M.S. and substantial (>5 years) experience with a demonstrated capacity to conduct research independently on a plurality of projects within a collaborative environment.

Desirable Skills and Techniques - Any of the following would be considered assets.

Cell Biology
  • Cell line and primary cell culture maintenance
  • Transfection and/or transduction techniques, especially of primary cells
  • Microscopy and/or other methodology for analyzing cellular morphology, behavior, or responses
  • Analysis of signaling responses

Immunology
  • T cell subset isolation from primary cells; culturing thereof
  • Common immunological assay procedures
  • Immune functional assays (target killing, ADCC, ADCP, cell signaling and reporter assays)
  • Immunophenotyping (RNA-seq, CITE-seq, scATAC-seq)
  • Flow cytometry

Molecular biology
  • RNA methods - isolation, purification, analysis of gene expression
  • PCR methods - for cloning or quantitative purposes (e.g., reverse-transcriptase qPCR, digital droplet qPCR)
  • Molecular Cloning - general DNA manipulation techniques, expression construct design
  • CRISPR/Cas9 methods and/or other methods directed at impacting gene expression

General
  • A demonstrated interest in research and development
  • A strong fundamental understanding of biological science and processes at a cellular and biochemical level
  • Critical thinking skills and a demonstrated facility with experimental design and results interpretation
  • Creative problem solving and tenacity when faced with difficult research hurdles
  • An ability to work independently and as part of a team
  • Excellent people, communication, and organizational skills
  • A willingness to change focus quickly and work on several projects simultaneously.

Physical Requirements

This position requires the ability to frequently and repetitively move and/or pour a minimum of 5lbs (up to 25lbs may occasionally be required) as well as other physical activities, including:
  • Constantly opening and closing lab receptacles, including removing and adhering plate seals, twisting caps, lifting lids.
  • Occasionally ascending/descending a ladder to retrieve lab supplies.
  • Constantly positioning self to pour or pipette reagents used for the lab process, including large and small volumes.

Benefits
  • Free catered lunch (Monday-Friday)
  • 100% employer-funded benefits package
  • Medical and Dependent Care flex spending account
  • 20 days PTO, accrual basis
  • 10 paid company holidays
  • 401(k), Safe Harbor plan and employer-matching retirement plans
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