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Associate Scientist, Biology Discovery

Employer
Denali Therapeutics
Location
South San Francisco, California, US
Salary
Competitive
Closing date
May 25, 2022

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Project Management, Biology
Salary Type
Salary
Employment Type
Full time
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Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

The Opportunity

In anticipation of the Company's growth plans, Denali Therapeutics is seeking an Associate Scientist focusing on drug discovery research and mechanistic biology related to neurodegenerative diseases. Reporting to a Senior Scientist, you will perform translational research, with a focus on developing and validating biochemical and cell-based assays to explore mechanisms of neurodegeneration and support therapeutic development.

Responsibilities
  • Perform research in a dynamic and collaborative environment
  • Design and implement experiments to investigate disease mechanisms and support drug candidate selection
  • Evaluate therapeutic candidates using biochemical assays, cell-based assays, and in vivo studies
  • Make detailed scientific observations, analyze data, interpret, and present results
  • Collaborate with colleagues in Biology Discovery, Medicinal Chemistry, Protein Sciences, Pharmacology, DMPK, Project Management, CMC, Toxicology, Early Development and Clinical Sciences to develop innovative research and develop novel drugs

Basic Qualifications

Master's degree and 1+ year of industry experience

OR

Bachelor's degree and 3+ years of industry experience

Preferred Qualifications
  • Degree in Biochemistry, Cell Biology or Neurobiology
  • Proficiency in a broad range of biochemical, molecular, and cellular techniques including Western blotting, qPCR, transfection, RNA interference, immunofluorescence and/or live imaging techniques, immunohistochemistry, and quantitative image analysis
  • Expertise in the culture of mammalian cell lines, primary cells, and/or iPSC-derived CNS cells
  • Experience in the field of membrane trafficking, membrane biology or lipid metabolism/transport
  • Highly organized with excellent analytical and critical thinking skills
  • Strong oral/written communication skills
  • Creative and inquisitive thinker who is eager to explore and learn new skills

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

#LI-GA1
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