Scientist/Senior Scientist/Principal Scientist, Molecular Biology 1245080

Our NY based (Soho area) client is seeking a Scientist/Senior Scientist/Principal Scientist to design and perform in vitro experiments to screen for and evaluate oligonucleotides for therapeutic potential from target selection to candidate selection. This is an exciting opportunity to join an early-stage company to help drive research, development, and strategic efforts to bring novel therapeutics to patients in need. This role will report directly to the VP of Discovery and Non-Clinical Development.

Primary Job Responsibilities:

• Participate in platform research projects focused on expanding utility, elucidating mechanism, and enhancing delivery and efficacy of RNA therapeutic platform
• Design and perform in vitro, ex vivo, and cell-based experiments to develop, validate and implement novel assays and technologies
• Recommend, design, and implement preclinical in vitro, ex vivo, and in vivo biomarker assays to support discovery and non-clinical development
• Experience in NGS library preparation and RNAseq and analyses strongly preferred
• Prepare and analyze samples from in vitro and in vivo experiments using a variety of biochemical and molecular biology techniques
• Optimize assay performance (precision, accuracy, robustness) and conduct sample testing to support drug development
• Author, review and approve SOPs, study protocols and other scientific documents
• Present key findings at scientific meetings, lab meetings, and to upper management
• Develop strong relationships and communicate effectively with internal colleagues
• Serve as the lead for collaborations with external partners

Primary Job Requirements:

• PhD degree with 1-5 years of experience or BS/MS 5-10 years of experience in pharmacology, molecular biology, cell biology, biochemistry or a related discipline
• Strong publication record with proven track record of independently driving scientific projects of high quality.
• Familiarity with robotic implementation and high throughput screening preferred
• Extensive experience with mammalian cell culture, including maintenance of primary cultures and established cell lines
• Extensive experience with standard biochemical and molecular biology techniques, including microscopy, western blot, ELISAs, and/or quantitative protein analyses
• Extensive experience in developing functional assays and interrogating molecular mechanism
• Experience with molecular and cell-based assays including molecular cloning, RNA transfection, nucleic acid and protein isolation, gene expression analysis (dPCR, RT-qPCR, end point PCR incl. primer design
• Experience with RNAseq and NGS library preparation preferred
• Experience with designing and conducting in vitro and ex vivo cell-based pharmacology and biology assays
• Ability to execute, troubleshoot and analyze experiments with minimal supervision
• Documentation of procedures and results in compliance with Electronic Lab Notebook guidelines
• Strong work ethic and the ability to work as a member of a highly collaborative team
• Excellent time and project management skills, and ability to work on multiple projects simultaneously

About Stratacuity:

Whether you are seeking a career change or simply interested in becoming part of our network, you will appreciate the ethics guiding each Stratacuity team member. We build lasting relationships with exceptional biopharmaceutical talent and take great care to protect your personal information. Upon receiving your inquiry, you may be directly contacted by a Stratacuity team member to discuss your career goals. We will not share your information with anyone without your direct prior consent.

Stratacuity is an Equal Employment Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stratacuity will consider qualified applicants with criminal histories in a manner consistent with the requirements of applicable law. If you have visited our website in search of information on employment opportunities or to apply for a position, and you require an accommodation in using our website for a search or application, please contact us.

Job Information

• Job ID: 62826649
• Location:
  New York, New York, United States
• Company Name For Job:stratacuity
• Job Type:Full-Time

View your connections at stratacuity LinkedIn
Please refer to the company's website or job descriptions to learn more about them.

Laboratory Scientist & NGS Associate 1253155

Burlington, Massachusetts, United States

2 days ago

Associate Director / Director, Analytical Development (Cell Therapy) 1234324

Cambridge, Massachusetts, United States

2 days ago

Associate Director/ Director LNP (Lipid Nanoparticle) Formulation 1251350

New York,New York,United States

Clinical Data Management Principal Data Manager

New York,New York,United States

Chemistry Manufacturing and Control (CMC),...

New York,New York,United States

(Associate) Director, Regulatory

United States

Insert additional messaging here.