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Senior Research Associate/Scientist I, Molecular Cell Biology, Protein Sciences

Ultragenyx Pharmaceutical Inc.
Novato, California, US
Closing date
May 22, 2022

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Academic / Research, Consultancy/Private Sector
Informatics / GIS
Salary Type
Employment Type
Full time
Why Join Us?

Be a hero for our rare disease patients

At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won't go - challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them.

Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth - so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.

If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team. During the COVID-19 pandemic, we are committed to the health and safety of our employees and prospective employees, which means at this time our interview processes may include virtual discussions, interviews, and onboarding. Please note that compliance with local regulations and safety protocols is a condition of employment at Ultragenyx. Elements of safety protocols may include, but are not limited to: work from home requirements, regular or symptom-based covid testing, providing valid evidence of vaccination, mask wearing, and physical distancing.

US based roles: Full vaccination against COVID-19 is a condition of employment at Ultragenyx. This requirement applies to almost all roles at Ultragenyx based in the U.S., with very limited exceptions. If you are unable to receive a COVID-19 vaccine due to a disability, serious medical condition, or because it would violate your sincerely held religious belief, you will have an opportunity to request a reasonable accommodation.

Roles based outside the US: If the role requires travel to the US or another country that requires evidence of covid vaccination for entry, candidates and employees will be required follow the local regulations and corporate policy regarding vaccination evidence submission.

Position Summary:

ultra-focused - Work together to fearlessly uncover new possibilities.

We seek a highly motivated and creative individual to join our Protein Sciences group to support and develop multiple therapeutic modalities for treating rare diseases. This position is part of the Research department in our Translational Science organization. It will expose the incumbent to research drug development, including providing guidance at project team meetings, contributing to manuscript preparation, patent applications, and attending conferences.

The candidate will develop processes for research-scale expression in mammalian hosts, including but not limited to, cell line engineering, cell line development, and media development. They will expand our recombinant protein research program evaluating and establishing new technology to produce/evaluate constructs to address critical questions working closely with our Bioinformatics team. They will implement tasks and work to contribute to the success of the group and the Research Department.

Work Model:

Core Lab & Ops: majority of the work requires being in the office or laboratory either pre, during or post pandemic.
Hands-on involvement with CHO and HEK293 cell line development and early-stage upstream process development.
Participate in generating stable cell lines using conventional or novel strategies to enhance protein production capacity.
Develop vector/DNA constructs for recombinant protein expression in HEK293 and CHO cells.
Work in a cross-functional team environment to produce reporter constructs.
Evaluate expression with appropriate biochemical and analytical techniques such as SDS-PAGE, HPLC, Western, ELISA, etc.
Work on complex issues where analysis of situations or data requires an in-depth evaluation of variable factors.
Maintain lab notebooks, author technical reports, and contribute to manuscripts/publications and patent applications.
Determine methods and procedures on new assignments, executing tasks independently.
Level commensurate with academic and/or biopharmaceutical experience, records of accomplishments, and depth of subject matter expertise.
Degree in Biological Science, Biochemistry, cell biology, or a related discipline
SRA: MS with 2+ years of experience, Bachelor's Degree with 4+ years of experience.
Scientist I: Normally requires a Ph.D. in a scientific discipline and a minimum of 0-2 years related or post-doctoral experience, an MS and a minimum of 2-5 years related experience; or a BA/BS and a minimum of 5-8 years related experience.
Scientist II: Normally requires a Ph.D. in a scientific discipline and a minimum of 2-5 years related or post-doctoral experience, an MS and a minimum of 5-8 years related experience, a BA/BS with a minimum of 8-10 years related experience.
Practical experience with mammalian cell culture techniques including sterile technique, passaging, and banking cells.
Experience in cell line development including transfection, electroporation, selection, expansion, cloning, sub-cloning, cell banking, and characterization would be considered a plus.
Experience with SDS-PAGE, Western Blot, ELISA, and other protein quantitation techniques.
Strong critical thinking, excellent communication, organization, and technical writing skills.
Strong problem-solving skills, ability to learn new techniques, and thrive in a collaborative cross-functional environment.
A high level of initiative, independence, enthusiasm for learning, and ability to work with minimal supervision is required.

Full Time employees across the globe enjoy a range of benefits, including, but not limited to:

· Generous vacation time and public holidays observed by the company
· Volunteer days
· Long term incentive and Employee stock purchase plans or equivalent offerings
· Employee wellbeing benefits
· Fitness reimbursement
· Tuition sponsoring
· Professional development plans

* Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status. Reasonable accommodation will be provided for qualified individuals with disabilities and for qualified disabled veterans in job application procedures, as required by applicable law. If you have any difficulty using our online application system and need an accommodation due to a disability, you may contact Talent Acquisition by calling: or by emailing us at . For electronic email and mail inquiries, please include a description of your requested accommodation, your name and contact information.

See our CCPA Employee and Applicant Privacy Notice.
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Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation. Inquiries on developing a recruiting relationship with us, may be directed to: .

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