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Scientist, Discovery Biology

BridgeBio LLC
San Francisco, California, US
Closing date
May 22, 2022

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Academic / Research, Consultancy/Private Sector
Informatics / GIS
Genetics, Biology
Salary Type
Employment Type
Full time
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About BridgeBio Oncology Therapeutics & BridgeBio Pharma

BridgeBio Oncology Therapeutics ("BBOT") is our team of researchers working to develop novel therapeutics to address dire unmet needs in oncology. Led by top scientists with extensive track records in drug development, like Frank McCormick and Eli Wallace, our team utilizes structure-based drug discovery techniques to target some of oncology's most challenging and validated molecular targets, including KRAS and PI3Kα. We are focused and committed to patients, scientific excellence, and operational agility, and we understand that every minute counts in our efforts to develop new therapies to transform the lives of people living with cancer. Our main oncology laboratory is located in South San Francisco, though our research collaborators span the country and globe.

BridgeBio is a biopharmaceutical company founded to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aim to translate today's discoveries into tomorrow's medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at

Who You Are

This is an exciting opportunity for a highly motivated Scientist with a strong background in cancer biology to join BridgeBio's search for innovative cancer therapeutics. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment to join our team as a laboratory-based leader.

  • Play a critical intellectual and technical role in discovering and developing novel small molecule cancer therapeutics
  • Design, conduct, and analyze studies to advance our understanding of cancer biology and propel drug discovery programs across our oncology pipeline, leveraging a diverse array of technologies and developing novel tools
  • Communicate your findings across seniority levels within and beyond BridgeBio
  • Collaborate closely with colleagues across scientific functions and departments, providing essential scientific expertise and guidance in an interdisciplinary environment
  • Provide scientific and technical leadership to junior team members
  • Initiate and maintain productive relationships with academic groups and CROs to complement and enhance our in-house capabilities
No matter your role at BridgeBio, successful team members are:

Patient Champions, who put patients first and uphold strict ethical standardsEntrepreneurial Operators, who drive towards practical solutions and have an ownership mindsetTruth Seekers, who are detailed, rational, and humble problem solversIndividuals Who Inspire Excellence in themselves and those around themHigh-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements
  • Ph.D. degree in a relevant discipline (e.g., cancer biology, genetics, cell biology)
  • 1+ years of relevant research, post-doc, or industry experience in a cell/molecular biology laboratory within an oncology setting
  • Broad knowledge of cancer biology and independence in critical thinking and scientific achievement demonstrated through high-quality, impactful publications
  • Experience with a wide range of cellular and biochemical techniques, including mammalian tumor cell culture and engineering, CRISPR, RNAi, immuno-blotting, NGS, IF/IHC, and FACS
  • Well-versed in basic bioinformatics techniques and the use of public data portals and platforms; programming experience is preferred but not required
  • Research experience in oncology drug discovery project teams, cancer cell-based assay design, assay development, and drug testing is advantageous
  • Strong problem-solving skills and a commitment to continuous learning and development
  • Excels in a highly-collaborative, fast-paced, and innovative environment

What We Offer
  • Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
  • A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
  • An unyielding commitment to always putting patients first. Learn more about how we do this here
  • A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
  • A place where you own the vision - both for your program and your own career path
  • A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
  • Access to learning and development resources to help you get in the best professional shape of your life
  • Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
  • Flexible PTO
  • Rapid career advancement for strong performers
  • Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
  • Partnerships with leading institutions
  • Commitment to Diversity, Equity & Inclusion - with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.
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