Senior Principal Research Scientist, Protein Sciences / Structural Biology
- Employer
- Vertex Pharmaceuticals
- Location
- San Diego County, California, US
- Salary
- Competitive
- Closing date
- May 22, 2022
View more
- Sector
- Academic / Research
- Field
- Conservation science
- Discipline
- Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Job DescriptionJob DescriptionVertex Pharmaceuticals is seeking a highly motivated and experienced protein structural biologist to join our San Diego Protein Sciences team. This team is responsible for all gene to structure work as well as cell-based approaches to study the mechanism of action of new and existing therapies. The team has a strong track record in applying structural biology to drug discovery.This critical role will:
- Support Vertex to continually strengthen internal capabilities, structure-based new drug design and exploit external centers of excellence.
- Lead a team of 3-4 scientists, set a clear direction and vision for the future success of the team and will evolve the team's use of cutting-edge technologies in structural biology and biophysics to develop novel and creative solutions to support drug discovery efforts.
- Design and performs sophisticated and complex, technically challenging experiments that impact critical project goals.
- Generates effective hypotheses to pursue project goals and encourages the use of new experimental approaches.
- Integrate and collaborate with related functions in Boston and Oxford and represent Vertex within the wider community in strategic partnerships.
- Established reputation with a track record in the field of expert membrane protein biochemistry, biophysics, and structural biology
- Demonstrated independent thought/creativity in science. Experience in applying emerging CryoEM and biophysical technologies to strengthen and improve current research capabilities
- Experience in leading a multi-disciplinary team to deliver impactful results and mechanism of action insights in support of drug discovery efforts
- Ability to integrate and collaborate with related Vertex functions in Boston and Oxford to achieve synergistic benefits for projects at all three centers
- Experience in managing personnel performance, goal setting and career growth development
- Excellent communication (oral and written) in articulating goals, objectives, hypotheses, and results to the group and larger cross-functional project teams
- Extensive experience interfacing with internal and external stakeholders to collaborate and execute on research programs, deliver results, and influence decision making
- Maintains the excellence of standards for structure and interpretation of all laboratory records, electronic database entries, internal reports, patents, and external communications from the team
- Ability to navigate and be successful in a fast-paced, cross-functional, and multi-disciplinary work environment
- 6+ years of SBDD experience in an industry environment, with proven track record of using structural information to drive chemical design from early hits to leads, to expedite the drug discovery process
- Bachelor's, Master's or PhD in cellular biology, biochemistry, biophysics, or related disciplines
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