Senior Research Associate, Discovery Biology

Sarepta Therapeutics is seeking a talented and highly motivated candidate to join our team as a Senior Research Associate in the Discovery Biology group. This person will participate in the research and development of Sarepta's new innovative RNA therapeutic platforms and programs for the treatment of patients with serious genetic diseases. The successful candidate will have strong technical background in cellular and molecular biology, and preferably experience with oligonucleotide drug discovery and delivery. The candidate will also be able to independently design and plan experiments, with supervisor review, to meet project goals. Ideal candidates will use their scientific capabilities and collaborative approach to partner with members of the Discovery Biology group and RNA research groups to drive forward the drug discovery process from target discovery through nomination of a clinical candidate.

Primary Responsibilities Include:

• Design and perform in vitro and cell-based experiments to develop and implement novel assays and technologies.
  
• Prepare and analyze samples from in vitro and in vivo experiments using a variety of biochemical and molecular biology techniques.
  
• Support the development and optimization of assays and experimental methods for the purpose or evaluating RNA-based therapeutics in disease models.
  
• Author and maintain good written records of laboratory procedures and data, study protocols and other scientific documents. Present key findings at internal and external scientific meetings.
  
• Interact and communicate with supervisor, study leads and other team members.
  
• Support day-to-day laboratory tasks.
  

Desired Education and Skills:

• B.S. or M.S. degree in Biology or related field with 5+ years of relevant laboratory research experience, or the equivalent experience obtained through working in a laboratory setting. Title will be commensurate with experience.
  
• Extensive experience and strong technical background with all aspects of molecular and cellular biology:
  
  • Proficient in cell culture practices and methodologies, using transformed and primary mammalian cells.
    
  • Compound/drug formulation, delivery, and high-throughput screening.
    
  • Nucleic acid methodologies and gene expression analysis including RNA/DNA isolation, RT-PCR, qPCR, ddPCR.
    
  • Protein analysis including western blot, ELISA, and immunohistochemistry.
    
  • Familiarity with laboratory software and data analysis software.
    
• Additional preferred experience:
  
  • Experience with tissue processing and analysis.
    
  • Oligonucleotide therapeutics.
    
• Excellent organization and communication skills and ability to collaborate effectively.
  

This position requires work on site at one of Sarepta's facilities in the United States. Candidates should be aware that Sarepta currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 in order to work on site. Newly hired employees must be vaccinated prior to their employment start date. Sarepta is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.