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Scientist - Neurobiology

Neurocentria, Inc.
Fremont, California, US
Closing date
May 26, 2022

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Academic / Research, Consultancy/Private Sector
Conservation science
Salary Type
Employment Type
Full time
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Pre-clinical Laboratory is in Fremont, CA.

Hours: Full-Time, M-F


Neurocentria is seeking a motivated and accomplished?Neuroscientist experienced with primary neuronal cultures and live imaging (synapse imaging is a plus). In this position, you will be responsible for establishing our protocols/platforms, designing and executing in vitro experiments, and analyzing, interpreting, and reporting results, related to drug discovery for neurodegenerative diseases.

Company Summary

Neurocentria is a late-stage biotechnology company dedicated to discovering and developing novel treatments for neurodegenerative and neuropsychiatric disorders, including ADHD, depression and Alzheimer's disease. Since 2005, our team has been innovating breakthrough therapies to address the pathophysiology of these disorders, prevent their progression or even reverse their course, reduce symptoms and improve patients' performance and quality of life.

While we are quickly moving forward with late-stage clinical trials on with our novel lead drug candidate, Neurocentria expands its pipeline for treating neurological and neuropsychiatric disorders.

Our novel therapy, NRCT-101SR, is a new class of treatment for neurological disorders, developed to act on new molecular targets. In preclinical studies, NRCT-101, the API of NRCT-101SR, increased synapse density and plasticity, improving synaptic function. Importantly, L-TAMS enhanced cognitive function and improved emotional regulation in young animals, and prevented synaptic loss and alleviated cognitive impairment in aged animals. Similar effects of L-TAMS were also seen in models of neuroinflammation.

In early-stage human clinical trials, NRCT-101 was shown to:

? Improve mood status in 3-7 days versus the several weeks it takes for most medications

? Address ADHD symptoms without imposing side effects

? Improve cognition for adults with late-life depression, anxiety, ADHD and Alzheimer's & Alzheimer's-like symptoms

? Produce no negative side effects

This novel approach was developed with our unique platform that allows us to visualize the function and plasticity of live synapses, offering a breakthrough opportunity to identify novel targets for augmenting synapse density/plasticity and function.

We are looking for an exceptional Neuroscientist to join our motivated team. This Scientist will work closely with the company's scientific leadership to design and execute in vitro drug discovery experiments. The startup nature of Neurocentria also provides multiple growth opportunities into other areas within the company.

Key Responsibilities

· Build, manage, and operate preclinical laboratory for translational research

· Isolate and culture primary neuronal cells

· Screen lead compounds in living neuronal culture models by live-cell microscopy using Immunofluorescent dyes and genetically encoded indicators

· Use a living-synapse imaging system to study drug-induced structural and functional changes of synapses

· Develop and execute in vitro? experiments to understand the molecular mechanisms underlying synapse function/plasticity, related to brain neurodegeneration

· Establish collaborations with external groups (academic and CROs) to conduct preclinical experiments to support clinical trials

· Write manuscripts for publication and scientific study reports for regulatory submission

· Participate in the design and execution of human bioanalytical biomarker studies

What we are looking for

· PhD in Neuroscience + at least 2 years of experience in either industry or academic postdoc

· Knowledge and expertise in the fields of neurobiology

· Proficient in Primary neuronal culture

· Expertise in Immunofluorescent dye, chemical indicator and genetically encoded indicator-based imaging

· Experience with time-lapse live cell imaging required (synapse imaging a plus)

· Familiar with Plasmid construction, extraction and transfection

· Working knowledge of biochemistry and molecular biology

· Ability to collect, analyze, and communicate complex scientific data both verbally and in writing

· Strong Data analysis skill

· Strong desire to work in a start-up environment

· Sense of urgency, initiative, ethics/integrity and innovation is required.

What we offer

· A competitive compensation package (commensurate on experience and qualifications)

· Comprehensive health/insurance plans including medical, dental and vision, life

· Competitive 401(k) investment options with corporate matching after 1 yr.

· Paid annual vacation, holiday and sick time off
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