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Scientist I/II, Cancer Cell and Systems Biology

Employer
REVOLUTION Medicines
Location
Redwood City, California, US
Salary
Competitive
Closing date
May 19, 2022

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
Scientist I/ II, Cancer Cell and Systems Biology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key member of our dynamic Biology team, and a key player in the Cancer Cell and Systems Biology group, you will:
  • Work on multiple project teams to advance existing programs; identify and validate new targets.
  • Lead efforts to profile small molecule development candidates, and elucidate drug mechanism of action.
  • Design, execute, interpret, and present experimental results to team members and senior leadership.
  • Offer a fresh perspective and provide input to multiple preclinical discovery and development projects.
  • Collaborate with biologists, pharmacologists, and data scientists to advance preclinical development projects through IND enabling studies.


Required Experience, Skills, and Education:
  • Ph.D. in Molecular/Cell Biology, Cancer Biology, or related field and 0-3 years postdoctoral or relevant biopharmaceutical industry research experience.
  • Proven track record of rigorous, quantitative, and detail-oriented science with expertise in mammalian cell culture, and cell-based assay development (e.g. MSD, HTRF, AlphaLISA, CellTiter-Glo, reporter).
  • Expertise in key cancer-related signaling pathways, and extensive hands-on experience in cell signaling pathway dissection and modulation with small molecules, CRISPR, RNAi, imaging, and other cellular and molecular biology techniques (e.g. Western blots, ELISA, qRT-PCR, next gen sequencing, molecular cloning).
  • Proficiency in cellular model development and gene editing with CRISPR preferred.
  • Experience analyzing large datasets and familiarity with publicly available cancer genome and drug sensitivity data (e.g. cBioPortal, TCGA, CCLE, DepMAP).
  • Ability to design and execute experiments with high level of independence, rigor, creativity, and curiosity.
  • Excellent written and verbal communication skills and ability to present to a wide variety of audiences.
  • Self-starter with strong interpersonal skills and a high degree of self-awareness.
  • Demonstrated ability to multi-task, anticipate challenges, troubleshoot, collaborate, and execute on goals as a member of an interdisciplinary team in a fast-paced small company environment.


Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company's offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.

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