Scientist I/II, Cancer Cell and Systems Biology
- Employer
- REVOLUTION Medicines
- Location
- Redwood City, California, US
- Salary
- Competitive
- Closing date
- May 19, 2022
View more
- Sector
- Academic / Research
- Field
- Conservation science
- Discipline
- Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Scientist I/ II, Cancer Cell and Systems Biology
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
As a key member of our dynamic Biology team, and a key player in the Cancer Cell and Systems Biology group, you will:
Required Experience, Skills, and Education:
Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company's offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
As a key member of our dynamic Biology team, and a key player in the Cancer Cell and Systems Biology group, you will:
- Work on multiple project teams to advance existing programs; identify and validate new targets.
- Lead efforts to profile small molecule development candidates, and elucidate drug mechanism of action.
- Design, execute, interpret, and present experimental results to team members and senior leadership.
- Offer a fresh perspective and provide input to multiple preclinical discovery and development projects.
- Collaborate with biologists, pharmacologists, and data scientists to advance preclinical development projects through IND enabling studies.
Required Experience, Skills, and Education:
- Ph.D. in Molecular/Cell Biology, Cancer Biology, or related field and 0-3 years postdoctoral or relevant biopharmaceutical industry research experience.
- Proven track record of rigorous, quantitative, and detail-oriented science with expertise in mammalian cell culture, and cell-based assay development (e.g. MSD, HTRF, AlphaLISA, CellTiter-Glo, reporter).
- Expertise in key cancer-related signaling pathways, and extensive hands-on experience in cell signaling pathway dissection and modulation with small molecules, CRISPR, RNAi, imaging, and other cellular and molecular biology techniques (e.g. Western blots, ELISA, qRT-PCR, next gen sequencing, molecular cloning).
- Proficiency in cellular model development and gene editing with CRISPR preferred.
- Experience analyzing large datasets and familiarity with publicly available cancer genome and drug sensitivity data (e.g. cBioPortal, TCGA, CCLE, DepMAP).
- Ability to design and execute experiments with high level of independence, rigor, creativity, and curiosity.
- Excellent written and verbal communication skills and ability to present to a wide variety of audiences.
- Self-starter with strong interpersonal skills and a high degree of self-awareness.
- Demonstrated ability to multi-task, anticipate challenges, troubleshoot, collaborate, and execute on goals as a member of an interdisciplinary team in a fast-paced small company environment.
Revolution Medicines currently requires that all personnel and visitors to its offices be fully vaccinated against COVID-19. This role will require that the employee meet with company employees and work from the company's offices. Given that these essential functions of the role must be performed on-site, this position requires full COVID-19 vaccination, subject to applicable law.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status.
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