Molecular Biology Research Scientist, Type 1 Diabetes
- Employer
- Vertex Pharmaceuticals
- Location
- Boston, Massachusetts, US
- Salary
- Competitive
- Closing date
- May 16, 2022
View more
- Sector
- Academic / Research
- Field
- Conservation science
- Discipline
- Biology
- Salary Type
- Salary
- Employment Type
- Full time
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Job DescriptionPosition Summary:Vertex seeks a Molecular Biologist to join the Vertex Cell and Genetic Therapies (VCGT) stem cell research group in Boston, MA. The group's mission is to discover and actualize the next generation of cell therapies for Type 1 diabetes. We are looking for a candidate with an interest in development and pancreatic islet biology with experience in molecular biology and cell ontology methods to support research in these areas. The candidate will work with the Stem Cell Research team on several discovery projects across diverse goals related to our cell product. The ideal candidate is scientifically independent and accustomed to taking initiative. The position requires strong communication and organizational skills, as well as proven adaptability and multitasking capability.Key Responsibilities:
- Perform human cell culture and drive discovery research efforts in stem cell and/or islet cell biology through cell-based assays and global bioinformatic approaches, employing techniques including library preparation, single-cell RNA sequencing, and gene expression analysis
- Lead team's use of analytical tools to evaluate cell fate of stem cells and differentiated stem cell-derived islets (SC-islets).
- Execute SOPs and stem cell differentiation campaigns (periodic weekend work is required).
- Work with cross-functional teams to plan, coordinate, and execute experiments.
- Present findings to the group and broader T1D teams, collaborate to summarize data into reports.
- Experience with Molecular Biology and Cell Ontology techniques, including but not limited to single-cell RNA Seq, Cell Lineage Tracing, etc.
- Familiarity with cell-based assays such as gene expression analysis (qPCR, nanostring, etc) and flow cytometry.
- Experience working at the interface of computational biology and the execution of lab-based experiments.
- Pluripotent stem cell culture experience (e.g., hESC and/or hiPSC) is desirable but not required. Candidates with model organism experience will also be considered.
- Must possess critical thinking and self-reliance to solve tasks independently or ask questions.
- Outstanding organization, multitasking capability.
- Proven track record of leading projects.
- Must possess the flexibility to quickly pivot as projects demand.
- Ph.D. (or equivalent degree) in Molecular and Cell Biology or related disciplines and 0-3 years of relevant post-doctoral employment experience. Candidates in Computational Biology will also be considered.
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