We are seeking a highly skilled research associate to lead mechanism of action and pharmacology studies on Dicerna's GalXC therapeutics. Major responsibilities include conducting in vivo studies on our pre-clinical and clinical candidates and conducting hands-on research. You will apply your expertise on animal dosing and surgery and deep understanding of the molecular and cellular biology to study liver diseases and play an important role in all phases of drug discovery and clinical development at Dicerna.
Play a role in guiding creative and rigorous biological research programs aimed at fully understanding the disease mechanism of Dicerna's pipeline.
Conduct efficacy, pharmacokinetic, pharmacodynamics, structure-activity-relationship and mechanisms of action studies of drug candidates
Use appropriate in vivo models to understand the mechanisms by which our drug candidates may contribute to adverse events in patients
Present working progress to team members in group meeting
Work closely with members of Dicerna's research team to develop in vivo strategies to quickly and effectively address key questions related to the safety and efficacy of our drugs.
Review literature and provide insights to research directions, while predominantly making hands-on contributions to the research
Bachelor's or Master's Degree in Biology, Pharmacology or a related field, with 1+ year of relevant in vivo experience.
Must be proficient in animal handling, dosing (intravenous injection, subcutaneous injection and oral gavage), various methods of blood collection (terminal & survival), and necropsy (with experience harvesting a wide range of tissues)
Ideally have experience performing molecular and cellular biology techniques, including but not limited to RNA preparation, RT-qPCR, western blot analysis, ELISA and immunohistochemistry/ immunofluorescence
Broad and deep understanding of signaling pathways and biological processes implicated in rare genetic liver diseases as well as the mechanism of action of RNAi therapies is desirable
Outstanding written and oral communication skills
A high level of motivation and demonstrated record of accomplishment throughout your career
The ability to work effectively as part of a team, in a fast-paced environment