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Scientist (Chemical Biology & Therapeutics)

St. Jude Children's Research Hospital
Memphis, Tennessee, US
Closing date
May 14, 2022

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Academic / Research
Informatics / GIS
Salary Type
Employment Type
Full time
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The laboratory of Dr. Anang Shelat within the Department of Chemical Biology is seeking a highly motivated scientist interested in leveraging the power of chemical biology to translate promising small molecule drug candidates into clinical trials for pediatric brain and solid tumors. Our lab employs state-of-the-art cell-based high-throughput and high-content screening technologies, advanced bioinformatics and machine learning approaches, and a unique collection of patient-derived orthotopic xenograft tumor models to: (a) investigate drug molecular mechanism of action, (b) identify drivers of drug resistance and sensitivity, and (c) develop combination strategies that enhance in vivo efficacy while preserving a therapeutic window. The lab is particularly interested in exploiting DNA repair defects, identifying and targeting addiction to anti-apoptotic BH3 proteins, and manipulating epigenetic state to selectively eliminate tumor cells.
The applicant must have a strong background in cancer biology and significant experience with in vivo studies, including basic animal husbandry, tissue procurement and processing, and murine xenografting. You must be comfortable working with 2D and 3D cell culture techniques. You will harness the world class resources available at St. Jude to accelerate research and seek new insights. The successful candidate will work alongside basic scientists, clinicians, and pharmacologists in a project team environment, with the goal of translating research findings into clinical trials for children with cancer.
  • Bachelor's degree in relevant scientific area is required.
  • Seven (7) years of relevant post-degree work experience is required
  • Five (5) years of relevant post-degree work experience is required with a Master's degree
  • Three (3) years of relevant post-degree work experience is required with a PhD

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children's Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
EEO Statement:
St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
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