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Sr. Research Associate / Scientist Microbiology

Employer
Actym Therapeutics, Inc.
Location
Berkeley, California, US
Salary
Competitive
Closing date
May 16, 2022

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Sr. Associate / Scientist, Microbiology

Actym Therapeutics, Inc. is a Berkeley, CA based venture-backed biotechnology company focused on developing novel immunotherapies intended to transform the treatment of cancer. Patients burdened with metastatic disease desperately need new and effective treatment options. Actym's revolutionary microbial-based technology platform is designed to overcome the hostile tumor microenvironment and promote durable anti-tumor immunity. This technology allows for the safe, programmed delivery of multiplexed immunological payloads to tumor-resident immune cells after IV dosing, in a single therapeutic composition. This paves the way for safely targeting immunological pathways that are intractable using conventional small molecule or antibody-based therapeutics due to systemic toxicities, which are of significant interest to the biopharma community. Actym recently completed a significant venture financing backed by top tier investors, and has announced a lead therapeutic candidate for clinical development.

Our people are our greatest asset. They bring scientific talents in immunology, microbiology, molecular biology, protein engineering, cancer biology, gene editing, process development, pharmacology, and clinical development to make the future happen now.

Position Summary

Actym Therapeutics is a rapidly-growing company seeking a highly motivated and creative Sr. Research Associate / Scientist to join our R&D Team. We are seeking an experienced microbiologist with additional expertise in immunology, oncology or related fields to join the R&D team's efforts to identify and develop novel immune-based therapies for the treatment of cancer and infectious diseases. We are a small team, looking to make a huge impact in the immunotherapy field. The ideal candidate will have multiple accountabilities, including microbial therapy production and characterization, and analytical testing methods to support preclinical drug development efforts at Actym. In addition to microbiology experience, the candidate must have proficiency in molecular biology techniques including: cloning, transformation, transduction, PCR, qPCR and qRT-PCR. Flow cytometry experience is a plus. The candidate will be responsible for producing bacterial strains and characterizing growth rates in vitro and in vivo. The candidate must have functional knowledge of microbial pathogenesis and immunology, and enjoy working in a fast-paced, team environment.

Essential Duties and Responsibilities
  • Microbial production experience is required
  • Expertise in routine microbial culture and characterization: serial dilution, CFU analysis, growth curves, antibiotic sensitivity
  • Significant experience with cloning is required: plasmid production and purification, PCR, cloning (Gibson assembly, In-Fusion, Gateway cloning, etc. experience a plus)
  • Experience with microbial genetics, preparation of cells for electroporation, phage transduction
  • Expertise in evaluation of cell-based gene expression using qRT PCR, western blot, ELISA, flow cytometry, microscopy
  • Biotechnology industry experience in a drug discovery environment is a plus
  • Experience with or knowledge of bacterial fermentation a plus
  • Oncology research experience is a plus
  • Analytical development knowledge is a plus
  • The candidate must be able to efficiently multi-task and contribute to multiple projects
  • Participate in multidisciplinary team efforts to make decisions on targets, drug candidates, and program progression
  • Attention to detail, highly organized, and able to efficiently communicate in oral and written form
  • Responsible for the integrity and quality of all data analyses, interpretation, and reporting of data to support pre/non-clinical sections of regulatory filings
  • Cultivates an open, transparent, and collaborative environment
  • Represent the company in external interactions at scientific conferences and to key opinion leaders including academic collaborators, strategic partners, and consultants

Requirements

We are seeking a hands-on microbiologist with additional experience in immunology or cancer biology to join our R&D group. The position requires a drive to provide an exceptional hands-on work product, a highly collaborative spirit, and a desire to meet or exceed quality and timeline expectations. A Ph.D. in Microbiology or Molecular Biology or Bachelor's or Master's degree in life sciences and minimum of 3 years of demonstrated experience working in laboratory setting is required.

The Ideal Candidate Shares Actym's Core Values:
  • Commitment: We are committed to bringing life-saving drugs to patients with cancer.
  • Accountability: We are accountable to each other and accept responsibility for our actions.
  • Quality: We are committed to the highest level of quality in our experiments, analyses, and communications with each other.
  • Respectfulness. We are respectful of each other and the diverse backgrounds that we bring to the team.
  • Decision making. Attuned to opportunity, we make intelligent decisions, adapting to create the best outcomes. We are decisive and undaunted by failure. We accept what doesn't work, learn from it, and get on to what does.
  • Collaboration. We achieve our goals together, inspiring, sharing, and creating as a team.
  • We do the right thing.


Work Environment

Work is performed in an office and laboratory environment. May be exposed to biological and chemical hazards. The employee is frequently required to stand; walk; sit; use hands to finger, handle, or feel and reach with hands and arms. Light to moderate lifting and carrying objects with a maximum lift of 30lbs. Must be able to work while wearing personal protective equipment such as safety glasses, gloves, and lab coats deemed necessary to protect testing and to protect employees. Work is to be performed on site.

About Actym

Actym offers comprehensive benefits including 401K, and generous health care coverage with Medical, Dental, Vision plans.

Disclaimer This job description is not necessarily a comprehensive list of all duties and responsibilities. The employer reserves the right to revise key functions of this position at any time. Actym is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

www.actymthera.com
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