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Research Associate/Senior Research Associate, Molecular Biology

Employer
Meet
Location
San Diego County, California, US
Salary
Competitive
Closing date
May 16, 2022

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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My client is an early-stage venture-backed gene therapy company based in San Diego, CA. We are an innovative and collaborative team developing next-generation medicines that will be first-in-class and best-in-class therapeutics for patients living with rare diseases.

Position Summary:

We are seeking a talented scientist for the payload synthesis group to enable platform development and discovery research efforts. This individual will be responsible for engineering novel gene expression constructs, which can be combined with non-viral delivery technologies in gene therapy applications. The ideal candidate will have extensive experience with molecular biology tools and techniques for synthesis, cloning, production, purification, analysis, and scale-up of various gene expression constructs. Additionally, the ideal candidate will be able to contribute to the design of novel mammalian expression cassettes (including optimizing promoters, codons, regulatory elements, etc.) and to facilitate utilization of innovative backbone structures. Previous experience applying synthetic biology tools to maximize gene expression in animal models of human disease is strongly desired. The ideal candidate is expected to be a strong collaborator who enjoys scientific discovery and can communicate effectively in a fast- paced, interdisciplinary environment.

Responsibilities:
  • Synthesize gene expression constructs as payloads for non-viral delivery vehicles
  • Engineer mammalian expression cassettes to maximize in vivo gene expression
  • Assist development of novel scaffold architectures that optimize payload functionality
  • Collaborate with a team of scientists to creatively solve problems and drive innovation
  • Design, execute, analyze, and interpret experiments
  • Maintain high standards for scientific integrity and accountability
  • Communicate across departments and support project teams


Requirements:
  • BS/MS Biology/Molecular Biology related fields - industry experience preferred
  • Molecular biology techniques such as qPCR, ddPCR, RNA/DNA extraction, and NGS
  • Modern cloning methods, such as Gibson assembly, for production and scale-up
  • Synthetic biology tools for genetic engineering
  • Design and optimization of gene expression cassettes
  • Mammalian cell culture and transfection of cell lines
  • Pallet Engineering
  • Cloning & Manufacturing DNA
  • Mammalian cell culture and transfection of cell lines
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