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Senior Associate Scientist, Engineered & Synthetic Biology

Employer
Bristol Myers Squibb
Location
Seattle, Washington, US
Salary
Competitive
Closing date
Jan 29, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Biology, Permitting
Salary Type
Salary
Employment Type
Full time
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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Position Summary

The BMS Immuno-Oncology and Cell Therapy Thematic Research Center (IO-CT TRC) is dedicated to research supporting development of novel cellular therapies based on two distinct and complementary platforms - Chimeric Antigen Receptor (CAR) and Engineered T Cell Receptor (eTCR) technologies. Our goal is to revolutionize medicine by re-engaging the body's immune system to treat cancer.

The Engineered T Cell Biology team, within the IO-CT TRC, is seeking an early career stage immunologist or molecular/cellular biologist for a Senior Associate Scientist or Scientist position. For this role, candidates with a cellular/cancer immunology or molecular/synthetic biology background and an interest in transcriptional and epigenetic regulation of T cell functions are preferred. Our team's overall goal is to discover and modulate key transcriptional and epigenetic circuits that regulate anti-cancer immune response by engineered T cells, for enhancing the overall potential of cellular therapies in BMS' Research & Early Development Pipeline.

This position is in a highly collaborative, innovative, and rapidly evolving environment and interfaces with teams and functions across IO-CT TRC. The ideal candidate will be responsible for designing and implementing innovative technologies to discover T cell regulatory circuits, which, upon modulation, can enhance the anti-cancer functionality of engineered T cells, thus permitting development of highly efficacious cancer cell therapies. Functioning under the supervision of a lead scientist, this position will design, organize and conduct independent experiments to advance project goals, as well as analyze and present findings cross-functionally to BMS teams.

The successful candidate will have working knowledge of immunology including T cell biology as well as familiarity or expertise with molecular biology techniques; ideal proficiencies include multi-dimensional flow cytometry, mammalian cell culture, methods of cell selection/enrichment, PCR/qPCR/ddPCR, design and use of viral vectors for gene delivery, and possess a strong organizational ability. Prior experience with human native or CAR/TCR-engineered T cells is preferred but not required. Familiarity with new generation sequencing (NGS) methods and practices is a plus.

Key Responsibilities
  • Design experimental strategies, execute and coordinate wet lab experiments and data analysis.
  • Design molecular biology tools (plasmid constructs and viral vectors).
  • High-dimensional flow cytometric characterization of T cell populations across longitudinal studies and purification of cell populations of interest.
  • Perform functional characterization of engineered T cells.
  • Work with the automation team to automate high-throughput experiments and assays.
  • Work with the molecular construction team to build, obtain and assay novel constructs of interest.
  • Work with data scientists across IO-CT TRC to design and perform NGS experiments and interpret data.
  • Nucleic acid isolation/handling, development of novel molecular assays.
  • Communicate progress and results at team meetings and cross-functionally across BMS.
  • Record keeping in an electronic notebook documenting experimental details.
  • Being flexible and amendable to working in a fast-paced, constantly evolving environment.


Qualifications & Experience
  • Level consideration based on prior experience related to the skillsets required of this position. Senior Associate Scientist: Bachelor's degree or Master's degree with 3-5 years of relevant experience. Scientist: Bachelor's or Master's degree with 5 years of experience or PhD with ~0-2 years of relevant experience.
  • Scientific interests in immuno-oncology and cell therapy.
  • Expertise in research methods in cell and molecular biology (T cell culture, tumor killing assays, multi-parametric flow cytometry, multi-dimensional characterization of T cell populations, cell sorting, gene delivery by viral and/or non-viral vectors).
  • Exposure to genome editing methods (e.g., ZFN, TALEN, CRISPR/Cas9) a plus.
  • Experience in NGS platforms and single-cell transcriptional/epigenetic profiling a plus.
  • Experience in cancer biology a plus.
  • Independent critical thinker.
  • Highly organized, with the ability to manage large amounts of complex data and independently track progress through varying stages of a project.
  • Self-motivated as an individual contributor, but also excited about working in a highly collaborative matrixed environment
  • Excellent written and verbal communication, and strong organizational skills to facilitate managing complex and demanding projects.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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