Co-op: Chemical Biology

Company Description

At Biogen, our mission is clear - we are pioneers in neuroscience. Biogen discovers, develops, and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Together, our employees create, commercialize, and manufacture transformative therapies for our patient population.?

We at Biogen are committed to building on our culture of inclusion and belonging that?reflects?the communities where we operate and the patients who we serve.?We are focused on strengthening our foundation to advance our overall Diversity, Equity and Inclusion (DE&I) strategy and, most importantly, ensure all our employees feel included.

As an intern or co-op at Biogen, you can expect to be placed on a real project, under the guidance of experience professionals and subject matter experts who are invested in your career and academic growth. We also ensure that you have plenty of opportunities to build your network, learn more about our organization through weekly lunch and learns led by leaders from across the company, and join us for several fun events.

Job Description

This application is for a 6-month student role from July - December 2022. Resume review begins in January 2022.

The Chemical Biology and Proteomics (CBP) group works on a wide range of research projects that support the Biogen pipeline by designing and executing robust and reproducible bioanalytical assays. CBP capabilities include but are not limited to higher-resolution interrogation of novel biology and the molecular mechanism of action of molecules that help advance the best drug candidates into the clinic.

Position Description

Biogen is searching for a highly motivated and collaborative?Co-op?to join the Chemical Biology and Proteomics (CBP) group within the Biotherapeutics and Medicinal Sciences department (BTMS). As a co-op, you will adapt your chemical biology skills to answer biomedically-focused research questions in cutting-edge laboratories.

This position will focus on understanding the interactions between small-molecule probes and their relevant RNA- and protein-binding targets. Day-to-day responsibilities will include but are not limited to assessing the activity of novel small molecule photoprobes in cellular systems, developing protocols for enriching crosslinked biological matter, and performing proteomics/RNA sequencing to identify binding targets.

Maintaining good written records of laboratory procedures and analyzing the results are also expected. You will participate and attend group/team meetings and will present at an internal poster session at the end of the program. The Co-op will also work closely with member(s) of the other functions within the BTMS to learn the details of on-going projects that will require novel method development.

Qualifications

• Good communication and interpersonal skills
• Familiarity with basic chemical biology target engagement concepts, such as activity-based protein profiling, photochemical crosslinking, click-chemistry, and chemoproteomics.
• Experience in the following laboratory skills:
• Basic laboratory techniques such as multichannel pipetting, gel electrophoresis, western blotting.
• Mammalian cell/tissue culture expertise, including practical experience with transfection (lipid-based, electroporation, or viral) and cell-based assays (such as cell-titer-glo or immunofluorescence)
• Affinity enrichment or co-immunoprecipitation workflows from mammalian cell lysate.
• Familiarity or previous expertise with chemoproteomics or quantitative proteomics protocols.
• Preferred experience in one or more of the following:
• Developing qPCR-based assays for quantifying cellular RNA.
• RNA sequencing or DNA footprinting workflows.
• Working knowledge of semi-automated liquid handling devices is highly desirable.
• Perform data analysis and visualization using appropriate software
• Efficiently manage time to enable the pursuit of multiple objectives in parallel
  

To participate in the Biogen Internship Program, students must meet the following eligibility criteria:

• Legal authorization to work in the U.S.
• At least 18 years of age prior to the scheduled start date
• Be currently enrolled in an accredited college or university
  

Education

Currently enrolled in a Master's or Ph.D. program in chemical biology, biology, biochemistry, or a related discipline.

Additional Information

All your information will be kept confidential according to EEO guidelines.