Scientist/Sr-Scientist, Translational Biology

We are seeking an individual to fill the Scientist, Translational Biology role as it is a key member of Dicerna's Biology teams, who will engage in multiple internal and partnered research and discovery efforts that aim to develop therapeutics to treat patients with rare and common diseases. We are seeking a highly skilled scientist with experience in target identification capable of identifying mechanism-of-action and conducting pharmacology studies. Primary responsibilities will include the design, management, and execution of in vivo animal models of disease to evaluate the efficacy, pharmacodynamics, and mechanisms of action of pre-clinical and clinical drug candidates. The successful candidate will interact closely with members of Translational Biology and other groups within Dicerna. You will apply your expertise in animal models and deep understanding of molecular and cellular biology to study liver and other diseases and play a key role in all phases of drug discovery and clinical development at Dicerna. Key Responsibilities Provide scientific and technical ability to assess new target and therapeutic hypotheses for the Translational Biology group Conduct efficacy, pharmacokinetics, pharmacodynamics, structure-activity-relationship and mechanisms of action studies of siRNA drug candidates Use appropriate in vivo models to understand the mechanisms by which our drug candidates may contribute to efficacy and potential adverse events in patients Present working progress to team members in a group meeting Work closely with Dicerna's research team members to develop molecular and cellular assays to quickly and effectively address key questions related to the safety and efficacy of our drugs. Review literature and provide insights to research directions, while making hands-on contributions to the research Develop in vivo model systems and technologies to evaluate efficacy, pharmacodynamics, and mechanisms of action of drug candidates Serve as a role model for compliant behavior that is consistent with the mission, vision and values of the Dicerna organization Qualifications PhD in Biology, Cell or Molecular Biology, or a related field, ideally with a >3 years industry experience Experience in designing and performing molecular and cellular biology techniques, including but not limited to administration of test compounds, collecting tissue samples RNA preparation, RT-qPCR, ELISA, immunohistochemistry, western blot In depth knowledge of, and hands-on experience with, in vitro and in vivo models used for mechanistic investigation and new target identification A true team player with high degree of energy and a passion for contributing to the discovery and development of novel therapeutics A mentor and coach for more junior people who might be reporting to you or others in the group Excellent verbal and written communication skills A documented and strong ability to collaborate with colleagues productively in a fast-paced environment

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