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Scientist I/II, Molecular Biologist

Affini T Therapeutics
Watertown, Massachusetts, US
Closing date
Jan 28, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Position Summary

Affini-T Therapeutics is an emerging biotechnology company focused on building a "best-in-class" TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic mutations enables development of solid tumor therapies. Through the application of gene editing and synthetic biology, we will focus on enhancing T-cell fitness to overcome the immunosuppressive tumor microenvironment.

Affini-T Therapeutics is announcing a Scientist, Synthetic Biology, opportunity at their Boston, MA Headquarters.
  • We are looking for an experienced and motivated molecular biologist who will play an important role in developing our TCR-T cell therapy platforms as well as applying innovative research biology approaches to develop our next-gen cell therapy products. The individual should be able to independently plan and execute research to discover and test TCRs specific for oncogenic driver mutations. The candidate is expected to collaborate across the entire cell therapy discovery spectrum, contributing to target identification and validation, as well as TCR engineering to improve the fitness of T cells or modulate the immunosuppressive signals from the tumor microenvironment. Requirements also include preparation of study reports, assay development, and regulatory documents. Previous experience in Immuno-Oncology and understanding of cell therapy field is preferred. The successful candidate will be a great team player, hard worker, and have outstanding communication skills

Essential Duties And Responsibilities

The major tasks for this position are as follows:
  • Design, execute and analyze in vitro studies to characterize TCR-engineered cell therapy products
  • Able to independently manage her/his workload, design and perform bench activities independently or with minimal supervision, able to drive novel research strategies
  • Able to manage project timelines and perform time sensitive experiments to drive discovery programs accordingly with departmental, functional and external stakeholders
  • Apply recent developments in cell therapy-related novel technologies to design and create the next generation cell therapy platforms
  • Plans and implements resolutions to technical problems/issues
  • Serves as a technical resource for junior staff and leverages expertise in laboratory technology as a functional resource/trainer
  • Contributes significantly and independently to multiple projects executed in parallel
  • Share biology lab operation, equipment and cell bank maintenance responsibilities
  • Accountable for the development of culture and capabilities within the TCR Discovery team

Desired And Required Qualifications

Education and Experience:
  • Ph.D. in Genetics, Molecular/Cellular Biology, or related scientific discipline with 2+ years relevant industry experience; or B.S./ M.S. in biology with 7+ years relevant industry experience
  • Strong technical skills in molecular biology including experience with single-cell technologies, library construction and NGS
  • Experience in vector design and viral transduction into primary and immortalized cell lines
  • Experience in flow cytometry and cell sorting
  • Familiarity with laboratory automation is a plus

The successful candidate will have the following attributes
  • Ability to work independently, generate, analyze and interpret data with scientific rigor and open mind
  • Able to troubleshoot critical issues or problems, and determine causes and possible solutions
  • Subject matter expertise and knowledge of applicable lab equipment and operations
  • Exercises good time management and prioritization skills and can successfully manage multiple tasks simultaneously
  • Ability to work well in a highly cross-functional team environment
  • Is very comfortable working with his/her team members in the laboratory
  • Is highly creative, collaborative, and thrives in a dynamic matrix environment
  • Proven skills as an effective team player who can engender credibility and confidence within and outside the company
  • Excellent oral and written communication skills, including writing, reviewing and editing scientific documents and presenting to a range of stakeholders, as well as scientific posters or lectures at professional conferences or events
  • Fit with Affini-T core values, mission and vision, including the highest personal values and ethical standards, creating a culture that fosters innovation
  • Possess the right attitude (agile, curious, positive, open-minded, "can-do" mindset), and have the ability and strong desire to "make things happen"

Physical Requirements
  • Sit for extended periods of time (2 or more hours)
  • Occasionally lift or carry up to 20 kg

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