Scientist I, Biology

Duties: The biology scientist will have experience interrogating cellular and molecular mechanisms as they relate to kinase target pathway modulation, off-target liabilities and resistance. The candidates primary role will be lab based and include cellular assays to support drug discovery efforts. This position offers the opportunity to impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment.

Responsibilities:

• Independently conduct, optimize and proactively troubleshoot cellular screening assays.
• Responsible for running cellular assays to screen small molecules, target validation and to establish PKPD relationships.
• Employ cellular and molecular assays such as isolation of RNA, PCR, Western blotting, ELISA, and flow cytometry to dissect mechanism of action of small molecules.
• Timely analyze and record detailed experimental data in an electronic laboratory notebook
• Actively participate in cross-functional projects.
• Present data to integrated project teams

Requirements:

• BS/MS in cellular molecular biology, cancer biology or related discipline with 1-3 years of laboratory experience in industry or academic setting.
• Experience in cell-based assays and mammalian cell culture, including transfection and transduction techniques, as well as stable cell line generation
• Familiar with state-of-the-art experimental techniques and the ability to implement new technologies when applicable
• Strong organizational and communication skills
• Strong problem solving and interpersonal skills to facilitate cross-functional collaboration
• Highly self-motivated , team player, capable of adapt to fast-paced and collaborative work environment
• Previous drug discovery experience in cancer biology and immunology is a plus
• Hands-on experience with MSD, AphaLISA , HTRF and Nanostring assay platforms is also a plus
• Prior experience with automation, plate-based assays and HTS is a plus