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Research Lab associate

Employer
University of California San Francisco
Location
San Francisco, California, US
Salary
Competitive
Closing date
Jan 24, 2022

View more

Sector
Academic / Research
Field
Conservation science
Discipline
Adaptive Management
Salary Type
Salary
Employment Type
Full time
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The Pinney Lab is starting at UC San Francisco and is seeking applicants for a research technician position using cutting-edge microfluidic technologies to understand the fundamental mechanisms that drive enzyme function and evolution. We are interested in probing how enzymes adapt in activity and stability to different temperatures, information that will teach us principles about enzyme function that can be applied to enzyme design.[1] Additionally, this work will illuminate the evolutionary mechanisms underlying enzyme adaptation to new and changing temperatures, information central to understanding the molecular pressures and adaptive avenues of organismal adaptation to climate change. Experiments will take advantage of a recently developed high-throughput microfluidic platform[2] to make quantitative measurements of enzyme activities and stabilities for thousands of enzyme variants in parallel, with the ultimate goal of developing molecular models for enzyme temperature adaptation that can be tested in vivo. Additionally, this position would involve building and setting up infrastructure for the lab.

This position is ideal for a candidate with a background in biophysics, bioengineering, biochemistry, or molecular biology, or a related field, interested in gaining further experience in an academic laboratory and working at the boundary of multiple disciplines. See more about our research here: pinneylabucsf.com

Requirements

· A bachelor's degree in biophysics, biochemistry, chemistry, molecular biology, bioengineering or a related field.

· Previous laboratory research experience required.

· Some programming experience preferred.

[1] Pinney, M. M. et al. Parallel molecular mechanisms for enzyme temperature adaptation. Science 371, doi: 10.1126/science.aay2784 (2021).

[2] Markin, C. J. et al. Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics. Science 373, doi: 10.1126/science.abf8761 (2021).

Job Type: Full-time

Pay: $50,000.00 - $65,000.00 per year

Schedule:
  • 8 hour shift

Work Location: One location
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