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Senior Scientist/Principal Scientist - Myeloid Biology

Pionyr Immunotherapeutics
South San Francisco, California, US
Closing date
Jan 26, 2022

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Academic / Research
Conservation science
Salary Type
Employment Type
Full time
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Senior Scientist/Principal Scientist - Myeloid Biology

Pionyr Immunotherapeutics is a growing, well-funded clinical stage South San Francisco-based immuno-oncology company focused on novel approaches to generate anti-tumor immunity. Pionyr is seeking a highly motivated immunologist or tumor biologist with expertise in myeloid biology. The candidate will be responsible for developing systems to interrogate myeloid cell-mediated regulation of tumor growth and evaluate myeloid-targeting strategies for anti-cancer treatment. The candidate will work closely with colleagues from antibody discovery, target discovery and validation teams, as well as manage external collaborations.

Specific responsibilities include but not limited to:

  • Develop in vitro, ex vivo and in vivo assay systems that interrogate both the function of myeloid cell populations and the activity of Pionyr's therapeutic molecules
  • Use murine tumor models and human tumor samples to understand the role of myeloid cells in sensitivity and resistance to therapeutic agents such as checkpoint inhibitors, chemotherapy, and/or radiotherapy
  • Closely collaborate with project and discovery teams to interrogate the mechanism-of-action of candidate antibodies targeting distinct myeloid subpopulations
  • Supervise and mentor junior staff members
  • Manage vendor and collaboration relationships
  • Contribute to Pionyr's research strategy by helping to expand the approaches used to target myeloid subpopulations within the tumor microenvironment
  • Support biomarker discovery efforts, including patient selection and stratification


  • PhD with at least 8 years of relevant research experience, preferably with 2-3 years of experience in an industry setting
  • Strong working knowledge of immuno-oncology and/or inflammation with emphasis on myeloid cells
  • Extensive knowledge of assays and systems for the interrogation of mouse and human immune cell function
  • Demonstrated experience with immune assays, including extensive experience with high-dimensional flow cytometry (14+ parameter) analysis of immune populations from blood, primary and secondary lymphoid tissues, and tumors
  • Experience planning, managing or conducting in vivo mouse syngeneic tumor studies (efficacy, pharmacodynamic, pharmacokinetic)
  • Expertise in myeloid biology as evidenced by authorship on high impact publications and patents
  • Experience with outsourcing and tech transfer of assays to third parties and CROs
  • Experience working in a fast-paced, cross-functional organization where collaboration is highly valued
  • Demonstrated ability to supervise and support career development of junior laboratory staff
  • [VJ1] Experience leading early drug development teams is a plus
  • Strong relationship-building and communication skills to empower teams and leverage strengths
  • Effective management of CROs and external partner collaborations
  • Excellent written and verbal communication skills, including preparation, organization, and synthesis of large amounts of data for presentation to internal and external audiences

Pionyr Immunotherapeutics Inc. offers competitive salaries, participation in company stock-incentive plans and benefits packages, in addition to a dynamic academic-driven science environment. If you would like to be part of a team-based and collaborative company developing innovative immuno-oncology therapeutics, please send your resume to
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