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Associate Scientist, Molecular Biology

Employer
Alloy Therapeutics, Inc.
Location
South San Francisco, California, US
Salary
Competitive
Closing date
Jan 24, 2022

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Sector
Academic / Research, Consultancy/Private Sector
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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Associate Scientist, Molecular Biology - South San Francisco, CA

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About Alloy Therapeutics

Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. We provide affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. Founded in 2017 and privately funded by visionary investors, we are headquartered in Boston, MA with European labs in Cambridge, UK, and expanding to San Francisco Bay Area. As a reflection of our relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. The team and company are rapidly expanding; successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

Who You Are

We are seeking a hard-working and detail-oriented bench Associate Scientist to build a new precision medicine platform. Our team needs someone with expertise RNA molecular biology to work with and mentor. We are looking for people with expertise in developing and optimizing various molecular, biochemical, and cellular assays and who want to be on the ground floor to build this internal capability at Alloy Therapeutics. We hope to hear from you!

Principal Responsibilities
  • Under supervision, this bench scientist position will work in a team to drive towards milestone completion at hyperspeed
  • Conceive, optimize, and run various biochemical, molecular and cellular assays such as, RNA extractions, real time qPCR, ELISA, and flow cytometry
  • Plan and conduct cell-based antisense oligonucleotide (ASO) library screens to create therapeutic candidates
  • Plan and conduct mechanistic study on ASO-mediated regulation of gene expression
  • Plan and conduct mechanistic investigation of factors affecting ASO safety
  • Keep records of experimental details and project outcomes
  • Prepare technical reports, summaries, protocols, and presentations

Required Qualifications And Skills
  • Degree in a relevant scientific field (Molecular Biology, Cell Biology, Biochemistry, etc)
  • B.S. with 5+ years of experience, M.S. with 3+ years, recent Ph.D. graduates
  • Title will be aligned with experience
  • Relevant experiment in molecular biology, mRNA splicing, and/or gene editing
  • Solid hand-on experience with commonly used techniques in cell, molecular biology, and biochemistry, such as cell culture, transfection, CRISPR KO, stable cell line selection, DNA/RNA/Protein extraction and analysis, cloning, qRT-PCR, real-time PCR, subcellular fractionation, ELISA, Western blot, Northern blot, immunoprecipitation, immunofluorescence staining and microscopy imaging
  • Ability to conduct data analysis, interpret experimental results, and independently draw conclusions
  • Excellent organizational and time management skills
  • Attention to detail, rigorous scientific thinking and ability of problem solving
  • Ability to manage multiple assignments effectively in a quickly evolving environment
  • Appropriate documentation, clear communication
  • An independent sense of urgency, persistence, and integrity
  • Excellent oral and written communication skills
  • Ability to be productive and successful in a fast-paced, intense work environment
  • Ability to work both independently and within a team

Preferred Qualifications And Skills
  • Industry experience preferred
  • Exposure to nucleic acid modalities, including siRNA, antisense oligonucleotide (ASO), mRNA technology
  • Experience in RNA splicing biology
  • Affinity to utilize new technologies and robotic automation for systematic consistency and efficiency

Benefits Include
  • Competitive base salary based on the position and your experience level
  • Significant opportunities for advancement and mentorship inside Alloy, through our venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
  • Equity compensation in a company with incredible growth potential and a 30+ year plan
  • Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
  • Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
  • Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
  • Additional benefits including adoption support, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others

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