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Director, Molecular Biology (Stealth start up)

Position located in Boston, MA.

Responsibilities of the Director, Molecular Biology (Stealth start up):

Designing a research program for the delivery of our technology using insights from virology and vector engineering
Evaluate new therapeutic opportunities for gene regulation, e.g. epigenome editing
Developing deep domain expertise through literature and engagement with external advisors
Independently execute studies, analyze data, share the conclusions and propose follow up experiments.
Partner with the disease biology and delivery science experts to optimize lead designs and screening methods
Effector engineering for improving activity and specificity
Establishment of effector characterization platform (efficacy, tox, specificity, packaging size)
Evaluation of delivery approaches for these technologies
Design and clone novel DNA constructs using state-of-the-art cloning strategies.
Form and test hypotheses using cultured cells employing a variety of cellular and molecular readouts.
Develop assays to facilitate testing experimental hypotheses.
Science communication and standardization
Examine data and prepare technical reports, summaries, and present at team meetings
Draft and review Protocols and SOPs.

Requirements of the Director, Molecular Biology (Stealth start up):

PhD in Life sciences with 8+ years of industry or academic experience.
Demonstrated experience with protein expression and translational regulation with a strong publication record.
Extensive knowledge and experience with molecular cloning and DNA plasmid design, nucleic acid isolation, PCR, qPCR and molecular detection techniques.
Extensive experience with mammalian tissue culture and cell-based assays.
Familiarity with next-generation sequencing methods.

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