We are recruiting a Structural Biologist to join the efforts in structural determination of protein-ligand and protein-protein complexes and contribute structural biology insights into the mechanism of action of novel chemical probes. The uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The structural biology efforts are expected to synergize with our chemical biology efforts and enable completion of impactful projects (e.g., Nat Commun 8:741, 2017; J Am Chem Soc 143:18467, 2021). This opportunity provides a unique research environment: in addition to basic research, lab members will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. The Lead Researcher will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, and technologists.
The successful candidate will have proved experience in expression construct design, molecular cloning, protein expression and purification, optimization of crystallization conditions, crystallization and structural determination of protein-ligand or protein-protein complexes using X-ray crystallography.
Experience in the following areas is a plus: purification and crystallization of nuclear receptors; utilization of both bacterial and insect expression systems; synchrotron data collection; biophysical assays; in silico modeling of protein-ligand and protein-protein interactions; preparation of manuscripts; along with a strong publication record.
Apply to be a part of the mission of St. Jude Children's Research Hospital: to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.
Bachelor's degree in relevant scientific area is required
PhD in Structural Biology or Chemical Biology is preferred
Five (5) years of relevant, post-degree work experience is required
Two (2) years of relevant post-degree work experience is required with a Master's degree
No experience is required with a PHD
Postdoctoral training is preferred
What We Offer:
Salary is highly competitive (comparable to industry) and are outstanding. Relocation assistance is available. Working at St. Jude provides the opportunity to make a tangible difference to pediatric cancer patient care and survival and St. Jude has been consistently ranked in Fortune magazine's "" list and is exceptionally positively reviewed on .
As of September 10, 2021, St. Jude Children's Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
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