Scientist: B Cell Biologist

Scientist, B Cell Biology

Location: South San Francisco

Position type: Regular Full Time

Walking Fish Therapeutics, Inc. is a privately-held, biotechnology company discovering and developing innovative cell-based therapeutics. Using its novel, cell-based discovery platform, Walking Fish is building a strong pipeline of oncology and regenerative medicine drug products. Walking Fish is using cell-based therapy to modulate the immune system and deliver therapeutic payloads into diseased tissue thereby minimizing systemic toxicity and allowing delivery of locally acting factors. Walking Fish has multiple patents for cell-based engineering and delivery technologies. For more information about Walking Fish, please visit Walking Fish's web site at www.walkingfishtx.com.

The Position

We are currently seeking an enthusiastic, highly motivated Scientist with a background in immunology and B cell biology and an interest in cell therapy to join our collaborative team of scientists. The ideal candidate will have a strong B cell immunology background and experience working with primary B cells and setting up cell-based functional assays to measure cytokine release, cell proliferation, and cell signaling as well as experience measuring cell therapy outcomes in animal models. A strong background in multi-color flow is desired.

As part of a multidisciplinary team of biologists, pharmacologists, and immunologists, the successful candidate will demonstrate the ability to carry out independent and cross-functional teamwork, apply critical thinking and generate reproducible, high quality data to inform development of Walking Fish's next generation cell therapy platforms.

The successful candidate will possess the following qualifications:

• Ph.D. scientist with 2+ years of post-degree industry or academic experience in immunology, with a specific focus on B cell biology and signaling, or B.S. or M.S. in Life Sciences, Biology, Immunology or related field with significant industry experience
• In-depth knowledge of B cell biology, immunology, and cell biology
• Experience in cell biology with proficiency in primary mammalian cell isolation and tissue culture, cell-based assays, and multi-parameter flow cytometry
• Familiarity with genetic engineering of primary immune cells using viral based strategies is highly desirable. Experience with culturing conditions and experience with characterization of engineered cell function using in vitro assays including cytokine/chemokine production, proliferation and cell signaling is highly desirable
• Assist in the design of new cell therapies and assist in in the design of murine models and experiments to evaluate genetically modified cell function in vivo
• Excellent oral and written communication and organization skills. Present scientific rationale, key data, issues and accomplishments to other members of the scientific team.
• Highly organized, detailed documentation of experimental procedures
• Strong computer skills, including commonly used programs: GraphPad Prism, Excel, PowerPoint, FlowJo
• Candidate values being part of a friendly and highly collaborative team