This job has expired

Scientist I-III, Translational Biology

Employer
Codexis, Inc.
Location
San Carlos, California, US
Salary
Competitive
Closing date
Jan 21, 2022

View more

Sector
Academic / Research, Consultancy/Private Sector
Field
Informatics / GIS
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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Are you ready to join our mission to improve the health of people and the planet? Do you have a passion for science and the transformational role that enzymes are playing? Come be part of our team at Codexis, Inc. We are a leading enzyme engineering company leveraging our proprietary CodeEvolver® technology platform to discover and develop novel, high performance enzymes and novel biotherapeutics.

Our Biotherapeutics division combines bioinformatics with directed evolution to uniquely tailor next generation biotherapeutics with transformative properties. We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an oral biologic, or gene therapy.

We are looking to hire a Scientist (I, II, III) to join our Biotherapeutics Translational Biology team.

If any of the below describes you, we would love to meet you!
  • Passionate about large-molecule drug discovery to improve the quality of life for patients with rare diseases.
  • Experienced or interested in novel technologies for protein engineering and directed evolution.
  • Excited about integrating protein evolution with gene therapy targeting paradigms to create first-in-class / best-in-class therapeutics.

In this role you will be responsible for:
  • Execution and oversight of preclinical studies in various in vivo, in vitro and ex vivo paradigms in support of Codexis' gene therapy portfolio. Experience with animal models of disease is required.
  • Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to support preclinical development programs. Collaborate with CRO's/KOL's to develop relevant animal models.
  • Understand and support/conduct the in vitro assays necessary to move programs forward, participate where appropriate in design.
  • Identification and validation of translational biomarkers ahead of moving to clinical trials.
  • Maintaining a current understanding of the scientific literature related to rare diseases where therapeutic enzymes and proteins could be impactful.
  • Representing the Translational Biology group as a member of cross-functional and collaborative project teams. When called upon, stepping into project leadership opportunities, and shepherding emerging projects from inception to the clinic.
  • Reviewing and analyzing scientific literature to identify opportunities and liabilities for protein therapeutics.
  • Excellent and effective oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Preparing and editing nonclinical documents for regulatory submission.
  • Participation in discussions with KOL's to obtain feedback on preclinical development.
  • Participate in hands on assay development / translational benchwork for downstream applications when necessary.

To be successful in this role, your background and experience should include:
  • PhD preferably in Biology, Pharmacology, or relevant life sciences, plus up to 4 years' experience in preclinical drug development; MS in relevant life sciences discipline with 5-10 years' experience in preclinical drug development will also be considered.
  • Advanced expertise in any the following areas is highly desired: animal protocol management, in vivo study design/execution, tissue processing, assay development.
  • Hands-on experience with in vivo pharmacology, experience in gene therapy delivery related to rare neurological and metabolic diseases is a plus.
  • Proficient understanding of AAV biology and experience with molecular biology and/or biochemical assay techniques is preferred.
  • Experience in designing, conducting, monitoring, and interpreting non-clinical efficacy studies with emphasis on translational biomarkers.
  • An excellent scientific background as demonstrated through publications in top peer- reviewed journals.
  • Successful track record of leading consultants, academic collaborations, and CROs.
  • Ability to work independently including data analysis and troubleshooting of experimental results.

What can Codexis offer you? (besides an amazing and collaborative culture?)
  • Full benefits your first day
  • 100% match on 401k (up to 4%)
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Student loan assistance
  • Commuter vouchers

PRINCIPALS ONLY

NO AGENCIES OR THIRD PARTIES

Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

Are you ready to join our mission to improve the health of people and the planet? Do you have a passion for science and the transformational role that enzymes are playing? Come be part of our team at Codexis, Inc. We are a leading enzyme engineering company leveraging our proprietary CodeEvolver® technology platform to discover and develop novel, high performance enzymes and novel biotherapeutics.

Our Biotherapeutics division combines bioinformatics with directed evolution to uniquely tailor next generation biotherapeutics with transformative properties. We engineer proteins with high efficacy and safety with the goal of delivering the therapeutic to patients as an oral biologic, or gene therapy.

We are looking to hire a Scientist (I, II, III) to join our Biotherapeutics Translational Biology team.

If any of the below describes you, we would love to meet you!
  • Passionate about large-molecule drug discovery to improve the quality of life for patients with rare diseases.
  • Experienced or interested in novel technologies for protein engineering and directed evolution.
  • Excited about integrating protein evolution with gene therapy targeting paradigms to create first-in-class / best-in-class therapeutics.

In this role you will be responsible for:
  • Execution and oversight of preclinical studies in various in vivo, in vitro and ex vivo paradigms in support of Codexis' gene therapy portfolio. Experience with animal models of disease is required.
  • Identifying, developing, and managing external collaborators (academic, industrial partners, and CROs) to support preclinical development programs. Collaborate with CRO's/KOL's to develop relevant animal models.
  • Understand and support/conduct the in vitro assays necessary to move programs forward, participate where appropriate in design.
  • Identification and validation of translational biomarkers ahead of moving to clinical trials.
  • Maintaining a current understanding of the scientific literature related to rare diseases where therapeutic enzymes and proteins could be impactful.
  • Representing the Translational Biology group as a member of cross-functional and collaborative project teams. When called upon, stepping into project leadership opportunities, and shepherding emerging projects from inception to the clinic.
  • Reviewing and analyzing scientific literature to identify opportunities and liabilities for protein therapeutics.
  • Excellent and effective oral and written communication with Codexis R&D, senior leadership, and external collaborators.
  • Preparing and editing nonclinical documents for regulatory submission.
  • Participation in discussions with KOL's to obtain feedback on preclinical development.
  • Participate in hands on assay development / translational benchwork for downstream applications when necessary.

To be successful in this role, your background and experience should include:
  • PhD preferably in Biology, Pharmacology, or relevant life sciences, plus up to 4 years' experience in preclinical drug development; MS in relevant life sciences discipline with 5-10 years' experience in preclinical drug development will also be considered.
  • Advanced expertise in any the following areas is highly desired: animal protocol management, in vivo study design/execution, tissue processing, assay development.
  • Hands-on experience with in vivo pharmacology, experience in gene therapy delivery related to rare neurological and metabolic diseases is a plus.
  • Proficient understanding of AAV biology and experience with molecular biology and/or biochemical assay techniques is preferred.
  • Experience in designing, conducting, monitoring, and interpreting non-clinical efficacy studies with emphasis on translational biomarkers.
  • An excellent scientific background as demonstrated through publications in top peer- reviewed journals.
  • Successful track record of leading consultants, academic collaborations, and CROs.
  • Ability to work independently including data analysis and troubleshooting of experimental results.

What can Codexis offer you? (besides an amazing and collaborative culture?)
  • Full benefits your first day
  • 100% match on 401k (up to 4%)
  • Generous flex time off
  • Fitness reimbursement
  • Free fitness classes
  • Back up child/dependent care
  • Student loan assistance
  • Commuter vouchers

PRINCIPALS ONLY

NO AGENCIES OR THIRD PARTIES

Codexis is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.

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