This role requires employees to be fully vaccinated against COVID-19 as a condition of employment, subject to a valid medical or religious accommodation.
The DMPK Bioanalytical group at ABC conducts quantitative bioanalysis assay(s) of large molecule therapeutics like mAb, ADC, fusion protein and bi-specifics for PK, PD and TK studies using various LBA and LCMS assays to support drug discovery and early development efforts.
The main responsibilities of the Biologist II position will be to support DMPK department Total LCMS sample quantitation, LBA sample operations and department sample management. Experience with HPLC and/or LCMS is preferred. Utilization of electronic sample management tools and automation systems is a plus. This position will require the ability to clearly communicate with multi-disciplinary scientific teams.
Duties & Responsibilities:
Perform bioanalytical sample preparation, LCMS BA assay execution to support pre-clinical PK and PK/PD and Toxicology studies with supervision
Assist with Mass Spec. system maintenance and operation
Perform bioanalytical sample preparation for Ligand binding BA assay (LBA) execution to support pre-clinical PK and PK/PD and Toxicology studies with supervision
Utilize and maintain electronic laboratory notebooks for study documentation
Utilize and maintain electronic systems for sample shipping and receiving management.
QC and store samples in appropriate areas, document and resolve discrepancies as needed.
Prepare items for shipping, noting shipment contents and communicate with teams for logistic details.
BS or MS Degree in biology, chemistry, biochemistry or related technical discipline with typically 3+ (BS), or 1+ (MS) years of relevant experience. Experience in biotech/pharmaceutical industry setting or academic core lab is preferred.
Hands-on experience in operating and troubleshooting HPLC and Triple quad MS platform and Analyst software is preferred
Highly organized and attention to detail.
Proven problem-solving ability.
Excellent written and verbal communication skills.
Proficiency with computers and software including Word, Excel and Powerpoint.
Experience in biotech/pharmaceutical industry setting or academic core lab is preferred.
Hands-on experience in operating and troubleshooting HPLC and Triple quad MS platform.
Experience with Analyst software preferred.
Experience in LCMS method development and strong data interpretation skills is required.