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Scientist/Senior Scientist Engineered T cell Biology

Employer
Bristol Myers Squibb
Location
Seattle, Washington, US
Salary
Competitive
Closing date
Jan 18, 2022

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Sector
Academic / Research
Field
Conservation science
Discipline
Biology
Salary Type
Salary
Employment Type
Full time
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At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The BMS Immuno-Oncology and Cell Therapy (IO-CT) Thematic Research Center (TRC) is dedicated to research supporting development of novel cellular immunotherapies based on two distinct and complementary platforms - Chimeric Antigen Receptors (CARs) and Engineered T Cell Receptors (eTCRs) technologies. Our goal is to revolutionize medicine by re-engaging the body's immune system to treat cancer.

The Engineered T Cell Biology Team is seeking an experienced and driven Scientist or Senior Scientist to help build and advance our cell therapy and immune-oncology portfolio. This position will be responsible for the evaluation of various modalities (eg; small molecule, genetic, epigenetic) that permit tuning of T cell functional responses and/or differentiation and will focus on the development of strategies, preclinical assays and screens that provide framework for the evaluation of various dysfunctional states. The successful candidate will have extensive knowledge of T cell biology including activation, signaling, differentiation and immune-regulation pathways and a track record of success in cell therapy or immuno-oncology drug discovery. This position is in a highly collaborative, innovate and rapidly evolving environment and interfaces with multiple teams and functions across the company. Our team's overall goal is to leverage attributes of CAR-T cell health, function and potency, as well as incorporate layered engineering strategies to improve the overall therapeutic potential of cellular therapies for BMS' Research and Clinical Development Pipelines.

Responsibilities for this role will include, but are not limited to, the following:
  • Application of T cell biology, differentiation and immune regulation expertise to develop strategies to build and/or extend assays that permit interrogation of T cells, CAR T or eTCR T cells in dysfunctional states
  • Produce gene- or small molecule/LMW-modified CAR T or eTCR T cells in scale-down/high-throughput settings and evaluate functionality utilizing in vitro screens
  • Provide T cell biology subject matter expertise and immunology guidance to cross-functional teams evaluating a diverse array of cell therapy engineering challenges
  • Leverage existing internal capabilities as well as be willing and eager to apply novel ideas from the literature and other disciplines to innovate in a rapidly evolving field
  • Help develop and mentor junior scientists on our team
  • Build constructive relationships across the organization and with our key business partners to achieve common goals


Qualifications:
  • PhD in immunology or molecular/cellular biology with 0-6 years of successful postdoctoral or industry experience, or a BS/MS with extensive industry experience in immunology that would fit the job qualifications.
  • Broad working knowledge of platforms and technologies to evaluate T cell function and/or heterogeneity including but not limited to in vitro stimulation assays, FACS, and DNA/RNA isolation for input into various molecular or NGS assays
  • Self-motivated and functional as an individual contributor as well as in a highly collaborative team-based environment
  • Excellent written and verbal communication, and strong organizational skills to facilitate managing multiple projects at once in a matrix environment
  • Prior experience writing technical reports and/or method development protocols
  • Familiar with general statistical practices


Preferred Qualifications:
  • Experience with high-dimensional (10-15+) FACS or spectral cytometry, transcriptional or epigenetic assessment, population labeling/tracking or fate-mapping, and/or other single-cell analytics
  • Working knowledge of T cell metabolism and/or assays a plus
  • Multivariate or machine learning data analytics experience a plus (eg; JMP, python, R)


Level consideration will be determined based on prior experience.

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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