Responsibilities • Execute analytical test methods to support bioprocess development of AAV candidates. - Will be running HPLC so experience is required • Develop and qualify analytical methods to measure and monitor key quality attributes for AAV therapeutic materials. • Verify and pre-validate analytical test methods in preparation for method transfer to GMP CMO facilities. • Stay up-to-date on state-of-the-art methodologies for AAV characterization. • Write, prepare and present technical data, technical reports and standard operating procedures (SOPs) for internal use and transfer to external sites. • Work independently in a collaborative, scientifically stimulating, patient-focused research environment.
hplc, chemistry, analytical chemistry, protein assays, AAV, Uv vis, assay development, assay, mass spectrometry, protein purification, chromatography, gel electrophoresis, capillary electrophoresis
Top Skills Details:
hplc,chemistry,analytical chemistry,protein assays
Additional Skills & Qualifications:
Requirements • BS or MS in Chemistry, Cell Biology, Biochemistry, or a related discipline with at least 2 years industry experience. - Potential Bio-Medical/Chemical Engineer as long as they've had protein + HPLC experience.. not med device types • Excellent problem-solving abilities for analyzing complex molecular entities. • HPLC/UPLC experience analyzing virus capsids, antibodies and/or other biologics materials by a variety of chromatographic methods (RP, SEC, IEX) and CE-based methods. • Knowledge on physicochemical characterization techniques, including but not limited to: AUC, MALS/DLS. • Managing contacts and communications with vendors, instrument services, software and instrument updates, and maintaining of the instruments. Including laboratory consumables related to the technical area. • Write, prepare, and present technical data, technical reports and standard operating procedures (SOPs) for internal use and transfer to external sites. • Proven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet schedules and deadlines. • Strong collaborative work ethic and excellent time management skills for ongoing testing in parallel with new method development, in a fast-paced, scientifically rigorous, cross-functional team environment.
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