Scientist - Protein Chemistry

We currently have an excellent opportunity for a talented Scientist with Protein Chemistry experience to join our team! Introduction: Xencor is an innovative, clinical-stage biopharmaceutical company located in the Los Angeles area-near Pasadena-and in San Diego. We use our pioneering XmAb® technology to discover and develop better biotherapeutics, antibodies and cytokines with improved function, with the goal of improving patient outcomes and quality of life. Our protein engineering capabilities and the modular nature of our XmAb technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are advancing a deep clinical pipeline of novel drug candidates, including eight bispecific antibodies and two engineered cytokines, and more programs are expected to start clinical testing in 2022. We also leverage our many XmAb technologies by collaborating with leading global biopharmaceutical companies, including Genentech and Janssen Biotech, among others, and including our partnerships, 20 XmAb drug candidates are advancing through clinical development. Three XmAb medicines, to treat patients with a range of serious illnesses, such as aggressive lymphoma, rare blood disorders and COVID-19, are now marketed worldwide by partners. Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees' value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks. Summary: Xencor is looking for a highly motivated biochemist Scientist to join our Protein Chemistry team focusing on protein isolation and characterization. This is an exciting opportunity to make a significant impact to the therapeutic discovery. The successful candidate will collaborate closely with the Protein Engineering, Antibody Discovery, Molecular Analysis and Biophysics teams to advance therapeutic molecule in research and development portfolio. Job duties: * Purification and characterization of antibodies and recombinant proteins produced from various mammalian expression systems using affinity and traditional chromatography. * Characterize proteins by analytical chromatography, CE-SDS and MALS. * Implementation and maintenance of automated protein purification methods as appropriate. * Participation in a highly matrixed cross-functional group. * Active hands-on participation in experiments is expected. * Maintain detailed record and communicating results to relevant teams. * The ideal candidate will self-driven, able to work in a fast-paced environment, and passionate about learning/implementing new technologies that enhance the discovery process. Job Qualifications: * Ph.D. in Biochemistry, Biophysics, Chemical Biology, Molecular or a related field with 2 or more years of industry experience. * Hands-on experience with the design, development, and optimization in recombinant protein purification/characterization techniques across multiple platforms and technologies is a must (e.g., FPLC, HPLC, CE-SDS, cIEF). * Ability to perform method development, write protocols, maintain detailed records and inventory are required. * Broad experience in protein chemistry, automation, structural biology, protein formulation, stability assessments, mass spectroscopy, protein labelling and conjugation techniques is highly desired. * Excellent written and oral communication skills are a must. * Excellent organizational skills passionate about adaptive learning, critical thinking, and the ability to work well in a team. Physical, Mental and Environment Demands: The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position. The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply. Specific mental demands for the position are listed above under requirements. In addition, mental demands for this position include: * Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources. * Ability to work and sustain attention with distractions and/or interruptions. * Ability to interact appropriately with a variety of individuals including vendors, customers and clients. * Ability to maintain regular attendance and be punctual. * Ability to understand, remember and follow verbal and written instructions. Occasional travel may be required, including travel between Xencor's Monrovia and San Diego offices. Work for this position is generally performed at Xencor's worksite and requires full-time commitment. Americans with Disabilities Act (ADA) Statement The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon your request as required to comply with applicable laws. If you have a disability and require assistance in this application process, please contact HR@xencor.com. To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions. Equal Employment Opportunity (EEO) Statement The Company is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender or gender identity, national origin, disability status, protected veteran status or any other characteristic protected by state or federal law. Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services and or resumes in no way creates an obligation or duty by Xencor, implied or otherwise.

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