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Post Doctoral Scientist - Developmental Biology of Pediatric Sarcoma

Nationwide Children's Hospital
Garden, Mississippi, US
Closing date
Jan 27, 2022

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Academic / Research
Modeling, Biology
Salary Type
Employment Type
Full time
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We are seeking a Post-Doctoral Scientist -This position is in the Center for Childhood Cancer and Blood Diseases in Dr. Genevieve Kendalls lab. We are seeking a motivated postdoctoral scholar to join our lab group. Our team is focused on developing basic and translational models of pediatric sarcomas, which are devastating and aggressive solid tumors with limited therapeutic options. Specifically, we study rhabdomyosarcoma, which is thought to arise from a misregulation of skeletal muscle developmental pathways. We use cell culture and transgenic zebrafish systems to understand the underlying biology of the disease and then apply that knowledge to identify therapeutic targets. Identified targets and therapeutic strategies are then confirmed via our model systems and through collaborations with the extensive expertise present in the Center for Childhood Cancer and Blood Diseases, Division of Hematology/Oncology and BMT, and in the Institute for Genomic Medicine. With guidance from Dr. Kendall, you will be responsible for leading an independent project that addresses our shared interests and aligns with your career goals. Your responsibilities will include performing experiments, determining the next steps, developing and implementing new and existing protocols, analyzing and presenting your results and conclusions, generating figures, and writing and publishing manuscripts. A background in zebrafish modeling of disease, skeletal muscle development, RNAseq, ATACseq and single cell sequencing is not required, but would be beneficial. The selected candidate must be professional, self-motivated, and dedicated, with strong communication and interpersonal skill sets that will fit our team. You will have many opportunities to learn new skill sets, present your work, develop professionally, and contribute to identifying new therapies for pediatric cancers in a dynamic and positive environment.

Why Nationwide Children's Hospital?:
The moment you walk through our doors, you can feel it. When you meet one of our patient families, you believe it. And when you talk with anyone who works here, you want to be part of it, too. Welcome to Nationwide Childrens Hospital, where Passion Meets Purpose.Here, Everyone Matters. Were 13,000 strong. And it takes every single one of us to improve the lives of the kids we care for, and the kids from around the world well never even meet. Kids who are living healthier, fuller lives because of the knowledge we share. We know it takes aCollaborative Cultureto deliver on our promise to provide the very best, innovative care and to fosternewdiscoveries, made possible by the most groundbreaking research. Anywhere.Ask anyone with a Nationwide Childrens badge what they do for a living. Theyll tell you its More Than a Job. Its a calling. Its achanceto use and grow your talent to make an impact thattrulymatters.Because here, we exist simply to help children everywhere.Nationwide Childrens Hospital. A Place to Be Proud

What Will You Be Doing?Designing and conducting laboratory-based experiments with transgenic zebrafish and cell culture based systems (utilizing skills/techniques such as microinjection, cloning, imaging, microdissection, flow cytometry, qPCR, immunofluorescence, immunohistochemistry, in situ hybridization, Western blots, RNAseq/ATACseq/single cell sequencing, generating new transgenic zebrafish lines, etc.) Collecting experimental data and maintaining an updated lab notebookCritically evaluating and interpreting data and determining next steps Mentoring and training staff and graduate studentsGenerating figures in Adobe Illustrator Writing and publishing scientific material, including manuscriptsPresenting research at regional, national, and international conferencesContributing to grant submissions for external funding Collaborating with other researchers at NCH/OSU, nationally, and internationally Performing miscellaneous related duties to help the team

What We Are Looking For?PhD, MD in Life Sciences, Biomedical Sciences, Cancer Biology or Developmental BiologyDesire to pursue a career in biomedical researchTechnical skills in a sub-set of the areas of research described above and a desire to quickly learn new skillsAbility to work independently on laboratory projects Proficiency in scientific writing Excellent communication skills Ability to train and mentor laboratory staff and graduate students The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individual so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under his/her supervision.EEO/M/F/Disability/Vet
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